CTGF Protein (AA 253-349, partial) (GST tag)

Catalog No. ABIN1046858

Product Details

Target: CTGF (Connective Tissue Growth Factor (CTGF))

Protein Type: Recombinant

Protein Characteristics: AA 253-349, partial

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This CTGF protein is labelled with GST tag.

Application: ELISA

Sequence: GKKCIRTPKI SKPIKFELSG CTSMKTYRAK FCGVCTDGRC CTPHRTTTLP VEFKCPDGEV MKKNMMFIKT CACHYNCPGD NDIFESLYYR KMYGDMA

Characteristics: Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.

Purity: 90 %

Application Details

Comment:

The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: 0.2-2 mg/mL

Buffer: Tris-based buffer, 50 % glycerol

Handling Advice: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week

Storage: -20 °C

Storage Comment: Store at -20 °C for extended storage, conserve at -20 °C or -80 °C

References

Igarashi, Bradham, Okochi, Grotendorst: "Connective tissue growth factor." in: The Journal of dermatology, Vol. 19, Issue 11, pp. 642-3, (1993) (PubMed).

Bradham, Igarashi, Potter, Grotendorst: "Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10." in: The Journal of cell biology, Vol. 114, Issue 6, pp. 1285-94, (1991) (PubMed).

Target Details

Target: CTGF (Connective Tissue Growth Factor (CTGF))

Alternative Name: Connective tissue growth factor protein (CTGF Products)

Synonyms: Ccn2 Protein, Fisp12 Protein, Hcs24 Protein, fisp-12 Protein, CCN2 Protein, HCS24 Protein, IGFBP8 Protein, NOV2 Protein, CTGRP Protein, ctgf Protein, hm:zeh1559 Protein, si:dkey-266k12.4 Protein, wu:fl25c03 Protein, zeh1559 Protein, zgc:136644 Protein, XCTGF Protein, ccn2 Protein, nov2 Protein, hcs24 Protein, igfbp8 Protein, CTGF Protein, si:ch211-173b8.2 Protein, connective tissue growth factor Protein, connective tissue growth factor a Protein, connective tissue growth factor L homeolog Protein, connective tissue growth factor b Protein, Ctgf Protein, CTGF Protein, ctgfa Protein, ctgf.L Protein, ctgf Protein, ctgfb Protein

Background: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

Molecular Weight: 38.5 kD

UniProt: P29279

Pathways: Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Growth Factor Binding