DR1-Associated Protein 1 (Negative Cofactor 2 Alpha) (DRAP1) (AA 4-198), (partial) protein (GST tag)

Details for Product No. ABIN1046948
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Protein Name
Synonyms fb26e10, zgc:56003, zgc:77337, wu:fb26e10, DRAP1, 2310074H19Rik, NC2-alpha
Protein Characteristics
AA 4-198, partial
Origin
Human
(9), (1), (1)
Source
Escherichia coli (E. coli)
(5), (4), (2)
Protein Type Recombinant
Purification tag / Conjugate
GST tag
Application
ELISA, SDS-PAGE (SDS)
Pubmed 5 references available
Quantity 50 μg
Options
Shipping to United States ( )
Availability Will be delivered in 9 to 11 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Sequence KKKKYNARFP PARIKKIMQT DEEIGKVAAA VPVIISRALE LFLESLLKKA CQVTQSRNAK TMTTSHLKQC IELEQQFDFL KDLVASVPDM QGDGEDNHMD GDKGARRGRK PGSGGRKNGG MGTKSKDKKL SGTDSEQEDE SEDTDTDGEE ETSQPPPQAS HPSAHFQSPP TPFLPFASTL PLPPAPPGPS APDEE
Characteristics The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Ref.1 Ref.2
Purity 90 %
Alternative Name Dr1-associated corepressor
Background Synonyms: Dr1-associated protein 1,Negative co-factor 2-alpha,NC2-alpha
Molecular Weight 48.6 kD
UniProt Q14919
Comment

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Restrictions For Research Use only
Format Lyophilized
Buffer PBS buffer, 20mM GSH
Storage -20 °C
Product cited in: Burkard, Planyavsky, Kaupe et al.: "Initial characterization of the human central proteome." in: BMC systems biology, Vol. 5, pp. 17, 2011 (PubMed).

Klejman, Pereira, van Zeeburg et al.: "NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein." in: Molecular and cellular biology, Vol. 24, Issue 22, pp. 10072-82, 2004 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Goppelt, Stelzer, Lottspeich et al.: "A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains." in: The EMBO journal, Vol. 15, Issue 12, pp. 3105-16, 1996 (PubMed).

Mermelstein, Yeung, Cao et al.: "Requirement of a corepressor for Dr1-mediated repression of transcription." in: Genes & development, Vol. 10, Issue 8, pp. 1033-48, 1996 (PubMed).

Validation Images
Catalog No. ABIN1046948
242.00 $
Plus shipping costs $45.00
Quantity
Price
50 μg
242.00 $

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)