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ICAM1 Protein (AA 28-480, partial) (GST tag)

ICAM1 Origin: Human Host: Escherichia coli (E. coli) Recombinant 90 % ELISA
Catalog No. ABIN1047208
  • Target See all ICAM1 Proteins
    ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 28-480, partial
    Origin
    • 17
    • 11
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 19
    • 11
    • 6
    • 3
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This ICAM1 protein is labelled with GST tag.
    Application
    ELISA
    Sequence
    QTSVSPSKVI LPRGGSVLVT CSTSCDQPKL LGIETPLPKK ELLLPGNNRK VYELSNVQED SQPMCYSNCP DGQSTAKTFL TVYWTPERVE LAPLPSWQPV GKNLTLRCQV EGGAPRANLT VVLLRGEKEL KREPAVGEPA EVTTTVLVRR DHHGANFSCR TELDLRPQGL ELFENTSAPY QLQTFVLPAT PPQLVSPRVL EVDTQGTVVC SLDGLFPVSE AQVHLALGDQ RLNPTVTYGN DSFSAKASVS VTAEDEGTQR LTCAVILGNQ SQETLQTVTI YSFPAPNVIL TKPEVSEGTE VTVKCEAHPR AKVTLNGVPA QPLGPRAQLL LKATPEDNGR SFSCSATLEV AGQLIHKNQT RELRVLYGPR LDERDCPGNW TWPENSQQTP MCQAWGNPLP ELKCLKDGTF PLPIGESVTV TRDLEGTYLC RARSTQGEVT RKVTVNVLSP RYE
    Characteristics
    Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.
    Purity
    90 %
    Top Product
    Discover our top product ICAM1 Protein
  • Comment

    The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Concentration
    0.2-2 mg/mL
    Buffer
    Tris-based buffer, 50 % glycerol
    Handling Advice
    Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C for extended storage, conserve at -20 °C or -80 °C
  • Tomassini, Graham, DeWitt, Lineberger, Rodkey, Colonno: "cDNA cloning reveals that the major group rhinovirus receptor on HeLa cells is intercellular adhesion molecule 1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 13, pp. 4907-11, (1989) (PubMed).

    Staunton, Marlin, Stratowa, Dustin, Springer: "Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families." in: Cell, Vol. 52, Issue 6, pp. 925-33, (1988) (PubMed).

    Simmons, Makgoba, Seed: "ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM." in: Nature, Vol. 331, Issue 6157, pp. 624-7, (1988) (PubMed).

  • Target
    ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))
    Alternative Name
    Intercellular adhesion molecule 1 protein (ICAM1 Products)
    Synonyms
    BB2 Protein, CD54 Protein, P3.58 Protein, Icam-1 Protein, Ly-47 Protein, MALA-2 Protein, ICAM Protein, ICAM-1 Protein, ICAM1 Protein, intercellular adhesion molecule 1 Protein, intercellular adhesion molecule-1 Protein, ICAM1 Protein, Icam1 Protein, ICAM-1 Protein
    Target Type
    Viral Protein
    Background
    ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
    Molecular Weight
    76.9 kD
    UniProt
    P05362
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling
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