Interleukin 15 (IL15) (AA 49-162), (full length) protein (His tag)

Details for Product No. ABIN1047241, Supplier: Log in to see
Protein Name
  • IL15
  • AI503618
  • IL-15
  • interleukin 15
  • IL15
  • Il15
Protein Characteristics
AA 49-162, full length
39
3
2
2
2
1
1
1
1
1
Origin
Human
73
29
16
4
4
3
3
3
2
1
1
1
1
1
Source
Escherichia coli (E. coli)
94
17
6
3
1
1
Protein Type
Recombinant
Purification tag / Conjugate
This IL15 protein is labelled with His tag.
Application
ELISA
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Sequence NWVNVISDLK KIEDLIQSMH IDATLYTESD VHPSCKVTAM KCFLLELQVI SLESGDASIH DTVENLIILA NNSLSSNGNV TESGCKECEE LEEKNIKEFL QSFVHIVQMF INTS
Characteristics Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.
Purity 90 %
Background Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.
Molecular Weight 16.9 kD
UniProt P40933
Pathways JAK-STAT Signaling, Glycosaminoglycan Metabolic Process
Comment

The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.

Restrictions For Research Use only
Format Lyophilized
Concentration 0.2-2 mg/mL
Buffer Tris-based buffer, 50 % glycerol
Handling Advice Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week
Storage -20 °C
Storage Comment Store at -20 °C for extended storage, conserve at -20 °C or -80 °C
Supplier Images
SDS-PAGE (SDS) image for Interleukin 15 (IL15) (AA 49-162), (full length) protein (His tag) (ABIN1047241) Interleukin 15 (IL15) (AA 49-162), (full length) protein (His tag)
Background publications Tagaya, Kurys, Thies, Losi, Azimi, Hanover, Bamford, Waldmann: "Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 26, pp. 14444-9, 1998 (PubMed).

Krause, Jandrig, Wernicke, Bulfone-Paus, Pohl, Diamantstein: "Genomic structure and chromosomal localization of the human interleukin 15 gene (IL-15)." in: Cytokine, Vol. 8, Issue 9, pp. 667-74, 1997 (PubMed).

Meazza, Verdiani, Biassoni, Coppolecchia, Gaggero, Orengo, Colombo, Azzarone, Ferrini: "Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines." in: Oncogene, Vol. 12, Issue 10, pp. 2187-92, 1996 (PubMed).

Grabstein, Eisenman, Shanebeck, Rauch, Srinivasan, Fung, Beers, Richardson, Schoenborn, Ahdieh: "Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor." in: Science (New York, N.Y.), Vol. 264, Issue 5161, pp. 965-8, 1994 (PubMed).