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c-MYC Protein (AA 1-439) (His tag)

MYC Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90% as determined by SDS-PAGE. ELISA, SDS
Catalog No. ABIN1047411
  • Target See all c-MYC (MYC) Proteins
    c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 1-439
    Origin
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 21
    • 3
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This c-MYC protein is labelled with His tag.
    Application
    ELISA, SDS-PAGE (SDS)
    Sequence
    MPLNVSFTNR NYDLDYDSVQ PYFYCDEEEN FYQQQQQSEL QPPAPSEDIW KKFELLPTPP LSPSRRSGLC SPSYVAVTPF SLRGDNDGGG GSFSTADQLE MVTELLGGDM VNQSFICDPD DETFIKNIII QDCMWSGFSA AAKLVSEKLA SYQAARKDSG SPNPARGHSV CSTSSLYLQD LSAAASECID PSVVFPYPLN DSSSPKSCAS QDSSAFSPSS DSLLSSTESS PQGSPEPLVL HEETPPTTSS DSEEEQEDEE EIDVVSVEKR QAPGKRSESG SPSAGGHSKP PHSPLVLKRC HVSTHQHNYA APPSTRKDYP AAKRVKLDSV RVLRQISNNR KCTSPRSSDT EENVKRRTHN VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT AYILSVQAEE QKLISEEDLL RKRREQLKHK LEQLRNSCA
    Characteristics
    Recombinant full-length human Myc proto-oncogene protein (MYC) cDNA (439 aa) constructed with a 6xHis-tag at the N-terminus was expressed in E. coli. It got purified up to 90% as determined by SDS-PAGE. Its predicted molecular weight is 52.8 kDa, but the observed is about 60 kDa. Posttranslational modification results in the higher actual molecular weight.
    Purity
    Greater than 90% as determined by SDS-PAGE.
    Top Product
    Discover our top product MYC Protein
  • Application Notes
    This MYC protein may find uses on specific antibody production, iPS generation mechanism mediated by human MYC in vitro, or related signaling transduction.
    Comment

    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.
    Buffer
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
    Handling Advice
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
    Storage
    -20 °C/-80 °C
    Storage Comment
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Bernard, Cory, Gerondakis, Webb, Adams: "Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours." in: The EMBO journal, Vol. 2, Issue 12, pp. 2375-83, (1984) (PubMed).

    Battey, Moulding, Taub, Murphy, Stewart, Potter, Lenoir, Leder: "The human c-myc oncogene: structural consequences of translocation into the IgH locus in Burkitt lymphoma." in: Cell, Vol. 34, Issue 3, pp. 779-87, (1983) (PubMed).

    Colby, Chen, Smith, Levinson: "Identification and nucleotide sequence of a human locus homologous to the v-myc oncogene of avian myelocytomatosis virus MC29." in: Nature, Vol. 301, Issue 5902, pp. 722-5, (1983) (PubMed).

  • Target
    c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
    Abstract
    MYC Products
    Synonyms
    MRTL Protein, MYCC Protein, bHLHe39 Protein, c-Myc Protein, CMYC Protein, c-myc Protein, C-MYC Protein, LOC100136746 Protein, ARC Protein, B430311C09Rik Protein, MYC Protein, NOP Protein, Nop30 Protein, RNCMYC Protein, mMyc Protein, AU016757 Protein, Myc2 Protein, Niard Protein, Nird Protein, cmyc Protein, zc-myc Protein, c-myc II Protein, myc-B Protein, myc2 Protein, myc1 Protein, CMyc Protein, zgc:55680 Protein, CG10798 Protein, D-Myc Protein, DM Protein, DMYc Protein, Dm Protein, Dmel\CG10798 Protein, Dmyc Protein, EG:BACN5I9.1 Protein, anon-WO03040301.171 Protein, bHLHe57 Protein, c-MYC Protein, d-myc Protein, dMYC Protein, dMyc Protein, dMyc1 Protein, da Protein, dm Protein, dm/dMyc Protein, dm/myc Protein, dmyc Protein, dmyc1 Protein, l(1)G0139 Protein, l(1)G0354 Protein, l(1)G0359 Protein, myc Protein, MYC proto-oncogene, bHLH transcription factor Protein, v-myc myelocytomatosis viral oncogene homolog Protein, nucleolar protein 3 (apoptosis repressor with CARD domain) Protein, myelocytomatosis oncogene Protein, MYC proto-oncogene, bHLH transcription factor a Protein, MYC proto-oncogene, bHLH transcription factor L homeolog Protein, MYC proto-oncogene, bHLH transcription factor S homeolog Protein, v-myc myelocytomatosis viral oncogene homolog (avian) Protein, MYC proto-oncogene, bHLH transcription factor b Protein, CG10798 gene product from transcript CG10798-RB Protein, MYC Protein, LOC100136746 Protein, Nol3 Protein, Myc Protein, myca Protein, myc.L Protein, myc.S Protein, mycb Protein
    Background
    Synonyms: Class E basic helix-loop-helix protein 39,bHLHe39,Proto-oncogene c-Myc,Transcription factor p64
    MYC is an oncoprotein that plays a central role in almost the whole oncogenic process, orchestrating proliferation, apoptosis, differentiation, and metabolism. As a transcription factor, MYC regulates transcription of numerous specific target genes that are involved in distinct cellular functions, such as cell cycle, protein biosynthesis, cell adhesion and cytoskeleton, metabolism, signal transduction, transcription, and translation. Aberrations in MYC protein, including mutations, overexpression, rearrangement, and translocation, have been linked to various hematopoietic tumors, leukemias, and lymphomas.
    Molecular Weight
    52.8 kDa
    UniProt
    P01106
    Pathways
    p53 Signaling, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effect
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