Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) protein (GST tag)

Details for Product No. ABIN1047807
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Protein Name
Origin
Mouse (Murine)
(30), (9), (3)
Source
Escherichia coli (E. coli)
(26), (5), (4), (3), (1), (1), (1)
Protein Type Recombinant
Purification tag / Conjugate
This TNFSF11 antibody is conjugated to GST tag
Application
ELISA, SDS-PAGE (SDS)
Pubmed 2 references available
Quantity 1 mg
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Characteristics Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
Purity 90 %
Alternative Name Tumor necrosis factor ligand superfamily member 11
Background Synonyms: Osteoclast differentiation factor Short name=ODF Osteoprotegerin ligand Short name=OPGL Receptor activator of nuclear factor kappa-B ligand Short name=RANKL TNF-related activation-induced cytokine Short name=TRANCE CD_antigen=CD254
Molecular Weight 45 kDa
Comment

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Restrictions For Research Use only
Format Lyophilized
Buffer 6M guanidine hydrochloride, 20mM Tris
Storage -20 °C
Product cited in: Anderson, Maraskovsky, Billingsley et al.: "A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function." in: Nature, Vol. 390, Issue 6656, pp. 175-9, 1997 (PubMed).

Wong, Rho, Arron et al.: "TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells." in: The Journal of biological chemistry, Vol. 272, Issue 40, pp. 25190-4, 1997 (PubMed).

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Catalog No. ABIN1047807
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