Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) protein (His tag)

Details for Product No. ABIN1047808
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Protein Name
Synonyms ODF, OPGL, sOdf, CD254, OPTB2, RANKL, TRANCE, hRANKL2, Ly109l, OPG, Trance, TNFSF11
Mouse (Murine)
(19), (14), (2)
Escherichia coli (E. coli)
(20), (5), (3), (3), (2)
Protein Type Recombinant
Purification tag / Conjugate
His tag
ELISA, Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN1047808
Quantity 1 mg
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Characteristics Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
Purity 90%
Alternative Name Tumor necrosis factor ligand superfamily member 11
Background Synonyms: Osteoclast differentiation factor Short name=ODF Osteoprotegerin ligand Short name=OPGL Receptor activator of nuclear factor kappa-B ligand Short name=RANKL TNF-related activation-induced cytokine Short name=TRANCE CD_antigen=CD254
Molecular Weight 25 kDa

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Restrictions For Research Use only
Buffer PBS Buffer
Storage -20 °C
Product cited in: Wong, Rho, Arron et al.: "TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells." in: The Journal of biological chemistry, Vol. 272, Issue 40, pp. 25190-4, 1997 (PubMed).

Anderson, Maraskovsky, Billingsley et al.: "A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function." in: Nature, Vol. 390, Issue 6656, pp. 175-9, 1997 (PubMed).

Hosts (20), (5), (3), (3), (2)
Reactivities (19), (14), (2)
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