Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14) (AA 1-239), (partial) protein (GST tag)

Details for Product No. ABIN1047820
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Protein Name
Synonyms TNFSF14, CD258, HVEML, LIGHT, LTg, TR2, HVEM-L, Ly113
Protein Characteristics
AA 1-239, partial
Origin
Human
(15), (5), (1)
Source
Escherichia coli (E. coli)
(10), (7), (2), (1), (1)
Protein Type Recombinant
Purification tag / Conjugate
GST tag
Application
SDS-PAGE (SDS), ELISA
Pubmed 2 references available
Quantity 50 μg
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Catalog No. ABIN1047820
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Sequence MEESVVRPSV FVVDGQTDIP FTRLGRSHRR QSCSVARVGL GLLLLLMGAG LAVQGWFLLQ LHWRLGEMVT RLPDGPAGSW EQLIQERRSH EVNPAAHLTG ANSSLTGSGG PLLWETQLGL AFLRGLSYHD GALVVTKAGY YYIYSKVQLG GVGCPLGLAS TITHGLYKRT PRYPEELELL VSQQSPCGRA TSSSRVWWDS SFLGGVVHLE AGEKVVVRVL DERLVRLRDG TRSYFGAFM
Characteristics Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
Purity 90 %
Alternative Name Tumor necrosis factor ligand superfamily member 14
Background Synonyms: Herpes virus entry mediator ligand,HVEM-L,Herpesvirus entry mediator ligand,CD258
Molecular Weight 53.6 kD
UniProt O43557
Comment

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Restrictions For Research Use only
Buffer 6M guanidine hydrochloride, 20mM Tris
Storage -20 °C
Product cited in: Mauri, Ebner, Montgomery et al.: "LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator." in: Immunity, Vol. 8, Issue 1, pp. 21-30, 1998 (PubMed).

Harrop, McDonnell, Brigham-Burke et al.: "Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth." in: The Journal of biological chemistry, Vol. 273, Issue 42, pp. 27548-56, 1998 (PubMed).

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