Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 31-210) protein (GST tag)

Details for Product No. ABIN1047844, Supplier: Log in to see
Protein Name
  • fpf
  • p55
  • tbp1
  • p55-r
  • tnf-r
  • tnfar
  • tnfr1
  • cd120a
  • tnfr55
  • tnfr60
  • xtnfr1
  • TNFR I
  • TNFRSF1A
  • TNFR1
  • CD120a
  • FPF
  • MS5
  • TBP1
  • TNF-R
  • TNF-R-I
  • TNF-R55
  • TNFAR
  • TNFR1-d2
  • TNFR55
  • TNFR60
  • p55-R
  • p60
  • TNF-R1
  • TNF-alphaR1
  • TNFRI
  • TNFRp55
  • TNFalpha-R1
  • Tnfr-2
  • Tnfr1
  • wu:fj65b10
  • zgc:85914
  • tumor necrosis factor receptor superfamily, member 1A
  • tumor necrosis factor receptor superfamily, member 1a
  • tnfrsf1a
  • TNFRSF1A
  • Tnfrsf1a
Protein Characteristics
AA 31-210
9
6
5
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Origin
Human
50
12
7
1
1
Source
Escherichia coli (E. coli)
28
7
7
6
3
3
2
1
1
1
1
1
Protein Type
Recombinant
Purification tag / Conjugate
This TNFRSF1A protein is labelled with GST tag.
Application
ELISA
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Sequence VPHLGDREKR DSVCPQGKYI HPQNNSICCT KCHKGTYLYN DCPGPGQDTD CRECESGSFT ASENHLRHCL SCSKCRKEMG QVEISSCTVD RDTVCGCRKN QYRHYWSENL FQCFNCSLCL NGTVHLSCQE KQNTVCTCHA GFFLRENECV SCSNCKKSLE CTKLCLPQIE NVKGTEDSGT
Characteristics Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.
Purity 90 %
Background Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Molecular Weight 47.6 kD
UniProt P19438
Pathways NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Hepatitis C
Comment

The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.

Restrictions For Research Use only
Format Lyophilized
Concentration 0.2-2 mg/mL
Buffer Tris-based buffer, 50 % glycerol
Handling Advice Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week
Storage -20 °C
Storage Comment Store at -20 °C for extended storage, conserve at -20 °C or -80 °C
Supplier Images
SDS-PAGE (SDS) image for Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 31-210) protein (GST tag) (ABIN1047844) Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 31-210) protein ...
Background publications Himmler, Maurer-Fogy, Krönke, Scheurich, Pfizenmaier, Lantz, Olsson, Hauptmann, Stratowa, Adolf: "Molecular cloning and expression of human and rat tumor necrosis factor receptor chain (p60) and its soluble derivative, tumor necrosis factor-binding protein." in: DNA and cell biology, Vol. 9, Issue 10, pp. 705-15, 1991 (PubMed).

Gray, Barrett, Chantry, Turner, Feldmann: "Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 19, pp. 7380-4, 1990 (PubMed).

Schall, Lewis, Koller, Lee, Rice, Wong, Gatanaga, Granger, Lentz, Raab: "Molecular cloning and expression of a receptor for human tumor necrosis factor." in: Cell, Vol. 61, Issue 2, pp. 361-70, 1990 (PubMed).

Loetscher, Pan, Lahm, Gentz, Brockhaus, Tabuchi, Lesslauer: "Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor." in: Cell, Vol. 61, Issue 2, pp. 351-9, 1990 (PubMed).

Nophar, Kemper, Brakebusch, Englemann, Zwang, Aderka, Holtmann, Wallach et al.: "Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form ..." in: The EMBO journal, Vol. 9, Issue 10, pp. 3269-78, 1990 (PubMed).