Asialoglycoprotein Receptor 1 Protein (ASGR1) (AA 62-291) (His tag)

Catalog No. ABIN1096056

Product Details

Target: Asialoglycoprotein Receptor 1 (ASGR1)

Protein Type: Recombinant

Protein Characteristics: AA 62-291

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This Asialoglycoprotein Receptor 1 protein is labelled with His tag.

Purpose: Recombinant Human Asialoglycoprotein Receptor 1/ASGPR1 (C-6His)

Sequence: QNSQLQEELR GLRETFSNFT ASTEAQVKGL STQGGNVGRK MKSLESQLEK QQKDLSEDHS SLLLHVKQFV SDLRSLSCQM AALQGNGSER TCCPVNWVEH ERSCYWFSRS GKAWADADNY CRLEDAHLVV VTSWEEQKFV QHHIGPVNTW MGLHDQNGPW KWVDGTDYET GFKNWRPEQP DDWYGHGLGG GEDCAHFTDD GRWNDDVCQR PYRWVCETEL DKASQEPPLL VDHHHHHH

Characteristics: Recombinant Human Asialoglycoprotein Receptor 1/ASGPR1 produced by transfected human cells is a secreted protein with sequence (Gln62-Ile291) of Human ASGPR1 fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 3 months

Target Details

Target: Asialoglycoprotein Receptor 1 (ASGR1)

Alternative Name: asgpr1 (ASGR1 Products)

Synonyms: ASGR1 Protein, ASGPR Protein, ASGPR1 Protein, CLEC4H1 Protein, HL-1 Protein, Asgr Protein, Asgr-1 Protein, ASGR Protein, RATRHL1 Protein, RHL1 Protein, asialoglycoprotein receptor 1 Protein, LOC721786 Protein, ASGR1 Protein, LOC489461 Protein, Asgr1 Protein, LOC101116157 Protein

Sub Type: Fusionprotein

Background: Asialoglycoprotein Receptor 1 (ASGPR1) is an endocytic recycling receptor, belongs to the long-form subfamily of the C-type/Ca2+-dependent lectin family. ASGPR consists of two noncovalently-linked subnits, ASGPR1 and ASGPR2. ASGPR1 mediates the endocytosis of plasma glycoproteins, recognizes terminal galactose and N-acetylgalactosamine units. When the ligand binds to to ASGPR1, results in the complex is internalized and transported to a sorting organelle, then ASGPR1 and ligand can be disassociated, ASGPR1 returns to the cell membrane surface.
Alternative Names: Asialoglycoprotein Receptor 1, ASGP-R 1, ASGPR 1, C-Type Lectin Domain Family 4 Member H1, Hepatic Lectin H1, HL-1, ASGR1, CLEC4H1

Molecular Weight: 27.43 kDa

UniProt: P07306

Pathways: Thyroid Hormone Synthesis