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CDH6 Protein (AA 22-615) (His tag)

CDH6 Origin: Human Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN1096176
  • Target See all CDH6 Proteins
    CDH6 (K-Cadherin (CDH6))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 22-615
    Origin
    • 11
    • 4
    • 2
    • 1
    • 1
    Human
    Source
    • 9
    • 3
    • 3
    • 2
    • 1
    Human Cells
    Purification tag / Conjugate
    This CDH6 protein is labelled with His tag.
    Purpose
    Recombinant Human Cadherin-6/K-Cadherin/CDH6 (C-6His)
    Sequence
    TPLSKRTSGF PAKKRALELS GNSKNELNRS KRSWMWNQFF LLEEYTGSDY QYVGKLHSDQ DRGDGSLKYI LSGDGAGDLF IINENTGDIQ ATKRLDREEK PVYILRAQAI NRRTGRPVEP ESEFIIKIHD INDNEPIFTK EVYTATVPEM SDVGTFVVQV TATDADDPTY GNSAKVVYSI LQGQPYFSVE SETGIIKTAL LNMDRENREQ YQVVIQAKDM GGQMGGLSGT TTVNITLTDV NDNPPRFPQS TYQFKTPESS PPGTPIGRIK ASDADVGENA EIEYSITDGE GLDMFDVITD QETQEGIITV KKLLDFEKKK VYTLKVEASN PYVEPRFLYL GPFKDSATVR IVVEDVDEPP VFSKLAYILQ IREDAQINTT IGSVTAQDPD AARNPVKYSV DRHTDMDRIF NIDSGNGSIF TSKLLDRETL LWHNITVIAT EINNPKQSSR VPLYIKVLDV NDNAPEFAEF YETFVCEKAK ADQLIQTLHA VDKDDPYSGH QFSFSLAPEA ASGSNFTIQD NKDNTAGILT RKNGYNRHEM STYLLPVVIS DNDYPVQSST GTVTVRVCAC DHHGNMQSCH AEALIHPTGL STGAVDHHHH HH
    Characteristics

    Recombinant Human Cadherin-6/K-Cadherin/CDH6 (C-6His)

    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Sterility
    0.2 μm filtered
    Endotoxin Level
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
    Top Product
    Discover our top product CDH6 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
    Handling Advice
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Storage
    4 °C/-20 °C/-80 °C
    Storage Comment
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    CDH6 (K-Cadherin (CDH6))
    Alternative Name
    Cadherin-6 (CDH6 Products)
    Synonyms
    KCAD Protein, K-cadherin Protein, cad6 Protein, cadherin-6 Protein, CAD6 Protein, c-cad6B Protein, cadherin 6 Protein, Cdh6 Protein, CDH6 Protein
    Background
    Recombinant Human Cadherin-6 produced by transfected human cells is a secreted protein with sequence (Ser54-Ala615) of Human CDH6 fused with a polyhistidine tag at the C-terminus.
    Cadherin-6 (CDH6) is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular region. Cadherin-6 has high expression in kidney, brain, and cerebellum, and may contribute to the formation of the segmental structure of the early brain, as well as the development of renal proximal tubules. Weak expression is also detected in lung, pancreas, gastric mucosa and cytotrophoblasts. As a classic cadherin, Cadherin-6 will form homodimers and promote intercellular adhesion with itself and, possibly, Cadherin-9 and -14.
    Molecular Weight
    67.43 kDa
    UniProt
    P55285
    Pathways
    Cell-Cell Junction Organization
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