CRNN Protein (AA 1-140) (His tag)
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- Target See all CRNN Proteins
- CRNN (Cornulin (CRNN))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-140
- Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CRNN protein is labelled with His tag.
- Purpose
- Recombinant Human Cornulin (N-6His)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MPQLLQNING IIEAFRRYAR TEGNCTALTR GELKRLLEQE FADVIVKPHD PATVDEVLRL LDEDHTGTVE FKEFLVLVFK VAQACFKTLS ESAEGACGSQ ESGSLHSGAS QELGEGQRSG TEVGRAGKGQ HYEGSSHRQS
- Characteristics
- Recombinant Human Cornulin is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Ser140) of Human Cornulin fused with a His tag at the N-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product CRNN Protein
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Cornulin (CRNN) (AA 1-495) protein (GST tag)
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Cornulin (CRNN) protein (Myc-DYKDDDDK Tag)CRNN Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
- Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Storage
- 4 °C/-20 °C/-80 °C
- Storage Comment
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months. - Expiry Date
- 3 months
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- Target
- CRNN (Cornulin (CRNN))
- Alternative Name
- cornulin (CRNN Products)
- Synonyms
- C1orf10 Protein, DRC1 Protein, PDRC1 Protein, SEP53 Protein, RGD1311778 Protein, Gm1015 Protein, cornulin Protein, CRNN Protein, Crnn Protein, LOC100359146 Protein
- Sub Type
- Fusionprotein
- Background
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Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. Cornulin involves in the mucosal/epithelial immune response and epidermal differentiation. Cornulin is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When Cornulin is overexpressed in oral squamous carcinoma cell lines, it regulates negatively cell proliferation by the induction of G1 arrest.
Alternative Names: Cornulin, 53 kDa Putative Calcium-Binding Protein, 53 kDa Squamous Epithelial-Induced Stress Protein, 58 kDa Heat Shock Protein, Squamous Epithelial Heat Shock Protein 53, Tumor-Related Protein, CRNN, C1orf10, DRC1, PDRC1, SEP53 - Molecular Weight
- 17.45 kDa
- UniProt
- Q9UBG3
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