IMPA2 Protein (AA 1-288) (His tag)

Catalog No. ABIN1096984

Product Details

Target: IMPA2 (Inositol(myo)-1(or 4)-Monophosphatase 2 (IMPA2))

Protein Type: Recombinant

Protein Characteristics: AA 1-288

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This IMPA2 protein is labelled with His tag.

Purpose: Recombinant Human Inositol Monophosphatase 2/IMPase 2 (N-6His)

Sequence: MGSSHHHHHH SSGLVPRGSH MKPSGEDQAA LAAGPWEECF QAAVQLALRA GQIIRKALTE EKRVSTKTSA ADLVTETDHL VEDLIISELR ERFPSHRFIA EEAAASGAKC VLTHSPTWII DPIDGTCNFV HRFPTVAVSI GFAVRQELEF GVIYHCTEER LYTGRRGRGA FCNGQRLRVS GETDLSKALV LTEIGPKRDP ATLKLFLSNM ERLLHAKAHG VRVIGSSTLA LCHLASGAAD AYYQFGLHCW DLAAATVIIR EAGGIVIDTS GGPLDLMACR VVAASTREMA MLIAQALQTI NYGRDDEK

Characteristics: Recombinant Human Inositol Monophosphatase 2/IMPase 2 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Lys288) of Human IMPA2 fused with a 6His tag at the N-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris, 2 mM DTT, pH 8.0.

Preservative: Dithiothreitol (DTT)

Precaution of Use: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: -80 °C

Storage Comment: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: IMPA2 (Inositol(myo)-1(or 4)-Monophosphatase 2 (IMPA2))

Alternative Name: Inositol Monophosphatase 2/IMPase 2 (IMPA2 Products)

Synonyms: zgc:110201 Protein, 2210415D20Rik Protein, AI326924 Protein, AW259601 Protein, inositol monophosphatase 2 Protein, inositol(myo)-1(or 4)-monophosphatase 2 Protein, inositol (myo)-1(or 4)-monophosphatase 2 Protein, IMPA2 Protein, impa2 Protein, MGYG_08537 Protein, Impa2 Protein

Sub Type: Fusionprotein

Background: Inositol monophosphatase 2, also known as Inositol-1(or 4)-monophosphatase 2, Myo-inositol monophosphatase A2 and IMPA2, is an enzyme which belongs to the inositol monophosphatase family. IMPA2 catalyzes the dephosphoylration of inositol monophosphate with cofactor Magnesium and Inhibited by high Li+ and restricted Mg2+ concentrations. IMPA2 plays an important role in phosphatidylinositol signaling. IMPA2 can use the myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. IMPA2 is a pharmacological target for lithium Li(+) action in brain, it is considered to have a role in schizophrenia and bipolar disorder.
Alternative Names: Inositol Monophosphatase 2, IMP 2, IMPase 2, Inositol-1(or 4)-Monophosphatase 2, Myo-Inositol Monophosphatase A2, IMPA2, IMP.18P

Molecular Weight: 33.5 kDa

UniProt: O14732