LYVE1 Protein (AA 20-238) (His tag)

Catalog No. ABIN1097116

Product Details

Target: LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1))

Protein Type: Recombinant

Protein Characteristics: AA 20-238

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This LYVE1 protein is labelled with His tag.

Purpose: Recombinant Human LYVE-1/HAR/XLKD1 (C-6His)

Sequence: LVQGSLRAEE LSIQVSCRIM GITLVSKKAN QQLNFTEAKE ACRLLGLSLA GKDQVETALK ASFETCSYGW VGDGFVVISR ISPNPKCGKN GVGVLIRKVP VSRQFAAYCY NSSDTWTNSC IPEIITTKDP IFNTQTATQT TEFIVSDSTY SVASPYSTIP APTTTPPAPA STSIPRRKKL ICVTEVFMET STMSTETEPF VENKAAFKNE AAGFGGVPTV DHHHHHH

Characteristics: Recombinant Human Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1/LYVE-1 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Leu20-Thr238) of Human LYVE-1 fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-Citrate,1 50 mM NaCl, pH 7.0.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 3 months

Target Details

Target: LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1))

Alternative Name: lyve-1 (LYVE1 Products)

Synonyms: LYVE1 Protein, XLKD1 Protein, CRSBP-1 Protein, HAR Protein, LYVE-1 Protein, 1200012G08Rik Protein, Crsbp-1 Protein, Lyve-1 Protein, Xlkd1 Protein, lymphatic vessel endothelial hyaluronic receptor 1a Protein, lymphatic vessel endothelial hyaluronan receptor 1 Protein, lyve1a Protein, LYVE1 Protein, Lyve1 Protein

Sub Type: Fusionprotein

Background: Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 is a single-pass type I membrane protein. LYVE-1 is a CD44 homolog found primarily on lymphatic endothelial cells 1. LYVE-1 mainly expressed in endothelial cells lining lymphatic vessels. While LYVE-1 functions is a Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. LYVE-1 plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). It may act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
Alternative Names: Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1, LYVE-1, Cell Surface Retention Sequence-Binding Protein 1, CRSBP-1, Extracellular Link Domain-Containing Protein 1, Hyaluronic Acid Receptor, LYVE1, CRSBP1, HAR, XLKD1

Molecular Weight: 24.6 kDa

UniProt: Q9Y5Y7

Pathways: Glycosaminoglycan Metabolic Process