MMP3 Protein (AA 18-477) (His tag)

Catalog No. ABIN1097161

Product Details

Target: MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))

Protein Type: Recombinant

Protein Characteristics: AA 18-477

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This MMP3 protein is labelled with His tag.

Purpose: Recombinant Human Matrix Metalloproteinase-3/MMP-3 (C-6His)

Sequence: YPLDGAARGE DTSMNLVQKY LENYYDLEKD VKQFVRRKDS GPVVKKIREM QKFLGLEVTG KLDSDTLEVM RKPRCGVPDV GHFRTFPGIP KWRKTHLTYR IVNYTPDLPK DAVDSAVEKA LKVWEEVTPL TFSRLYEGEA DIMISFAVRE HGDFYPFDGP GNVLAHAYAP GPGINGDAHF DDDEQWTKDT TGTNLFLVAA HEIGHSLGLF HSANTEALMY PLYHSLTDLT RFRLSQDDIN GIQSLYGPPP DSPETPLVPT EPVPPEPGTP ANCDPALSFD AVSTLRGEIL IFKDRHFWRK SLRKLEPELH LISSFWPSLP SGVDAAYEVT SKDLVFIFKG NQFWAIRGNE VRAGYPRGIH TLGFPPTVRK IDAAISDKEK NKTYFFVEDK YWRFDEKRNS MEPGFPKQIA EDFPGIDSKI DAVFEEFGFF YFFTGSSQLE FDPNAKKVTH TLKSNSWLNC VDHHHHHH

Characteristics: Recombinant Human Matrix Metalloproteinase-3/MMP-3 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Tyr18-Cys477) of Human MMP-3 fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, 0.05 % Brij35, 10 % Glycerol, pH 7.5.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: -80 °C

Storage Comment: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))

Alternative Name: mmp-3 (MMP3 Products)

Synonyms: CHDS6 Protein, MMP-3 Protein, SL-1 Protein, STMY Protein, STMY1 Protein, STR1 Protein, SLN-1 Protein, SLN1 Protein, STR-1 Protein, Stmy1 Protein, Str1 Protein, MMP10 Protein, chds6 Protein, mmp-3 Protein, mmp13 Protein, mmp3 Protein, sl-1 Protein, stmy Protein, stmy1 Protein, str1 Protein, matrix metallopeptidase 3 Protein, matrix metallopeptidase 3 (stromelysin 1, progelatinase) Protein, matrix metallopeptidase 3 L homeolog Protein, MMP3 Protein, Mmp3 Protein, mmp3.L Protein

Sub Type: Fusionprotein

Background: MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. The MMP-3 enzyme degrades collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 crucial in connective tissue remodeling.[3] The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.
Alternative Names: Stromelysin-1, SL-1, Matrix metalloproteinase-3, MMP-3, Transin-1, MMP3, STMY1

Molecular Weight: 53.26 kDa

UniProt: P08254