CDKN2C Protein (AA 1-168) (His tag)

Catalog No. ABIN1097278

Product Details

Target: CDKN2C (Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) (CDKN2C))

Protein Type: Recombinant

Protein Characteristics: AA 1-168

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This CDKN2C protein is labelled with His tag.

Purpose: Recombinant Human Cyclin-Dependent Kinase 4 Inhibitor C/CDKN2C (N-6His)

Sequence: MGSSHHHHHH SSGLVPRGSH MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP EIARRLLLRG ANPDLKDRTG FAVIHDAARA GFLDTLQTLL EFQADVNIED NEGNLPLHLA AKEGHLRVVE FLVKHTASNV GHRNHKGDTA CDLARLYGRN EVVSLMQANG AGGATNLQ

Characteristics: Recombinant Human Cyclin-Dependent Kinase 4 Inhibitor C/CDKN2C is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Gln168) of Human CDKN2C fused with a His tag at the N-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 8.0.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 3 months

Target Details

Target: CDKN2C (Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) (CDKN2C))

Alternative Name: p18-INK4c (CDKN2C Products)

Synonyms: CDKN2C Protein, p18 Protein, ink4c Protein, p18-ink4c Protein, INK4C Protein, p18-INK4C Protein, C77269 Protein, INK4c Protein, INK4d Protein, p18INK4c Protein, cyclin dependent kinase inhibitor 2C Protein, cyclin-dependent kinase inhibitor 2C Protein, cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) Protein, CDKN2C Protein, cdkn2c Protein, Cdkn2c Protein

Sub Type: Fusionprotein

Background: Cyclin-Dependent Kinase 4 Inhibitor C (CDKN2C) is a member of the INK4 family of cyclin dependent kinase inhibitors. CDKN2C contains 4 ANK repeats and interacts with CDK4 or CDK6. Highest levels of CDKN2C can be found in skeletal muscle, pancreas, and heart. CDKN2C inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB and prevent the activation of the CDK kinases. Studies have been shown the roles of CDKN2C gene in regulating spermatogenesis, as well as in suppressing tumorigenesis.
Alternative Names: Cyclin-Dependent Kinase 4 Inhibitor C, Cyclin-Dependent Kinase 6 Inhibitor, p18-INK4c, p18-INK6, CDKN2C, CDKN6

Molecular Weight: 20.3 kDa

UniProt: P42773

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases