SCO1 Protein (AA 132-300) (GST tag)

Catalog No. ABIN1097478

Product Details

Target: SCO1 (SCO1 Cytochrome C Oxidase Assembly Protein (SCO1))

Protein Type: Recombinant

Protein Characteristics: AA 132-300

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This SCO1 protein is labelled with GST tag.

Purpose: Recombinant Human Protein SCO1 Homolog Mitochondrial SCO1/SCOD1 (N-GST)

Sequence: GSPEFHMGKP LLGGPFSLTT HTGERKTDKD YLGQWLLIYF GFTHCPDVCP EELEKMIQVV DEIDSITTLP DLTPLFISID PERDTKEAIA NYVKEFSPKL VGLTGTREEV DQVARAYRVY YSPGPKDEDE DYIVDHTIIM YLIGPDGEFL DYFGQNKRKG EIAASIATHM RPYRKKS

Characteristics: Recombinant Human Protein SCO1 Homolog, Mitochondrial/SCO1 is produced by our E. coli expression system. The target protein is expressed with sequence (Gly132-Ser300) of Human SCO1.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 50 mM PB, 1 mM DTT, pH 7.2.

Preservative: Dithiothreitol (DTT)

Precaution of Use: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 3 months

Target Details

Target: SCO1 (SCO1 Cytochrome C Oxidase Assembly Protein (SCO1))

Alternative Name: Protein SCO1 Homolog Mitochondrial (SCO1 Products)

Synonyms: SCOD1 Protein, 2610001C07Rik Protein, D11Bwg1310e Protein, SCO1 Protein, RGD1559538 Protein, SCO1, cytochrome c oxidase assembly protein Protein, SCO1 cytochrome c oxidase assembly protein Protein, SCO1 Protein, Sco1 Protein, sco1 Protein

Background: Protein SCO1 Homolog, Mitochondrial (SCO1) is a member of the SCO1/2 family. SCO1 has a homodimer structure. SCO1 is located in mitochondrion and is highly expressed in muscle, heart, and brain. It is characterized by high rates of Oxidative Phosphorylation (OxPhos). SCO1 is thought to play a important role in cellular copper homeostasis, mitochondrial redox signaling and insertion of copper into the active site of COX. The defects of SCO1 can result in Mitochondrial Complex IV Deficiency (MT-C4D). A disorder of the mitochondrial respiratory chain has heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs.
Alternative Names: Protein SCO1 Homolog Mitochondrial, SCO1, SCOD1

Molecular Weight: 20.14 kDa

UniProt: O75880

Pathways: Sensory Perception of Sound, Transition Metal Ion Homeostasis, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity