CLIC2 Protein (AA 1-247) (His tag)
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- Target See all CLIC2 Proteins
- CLIC2 (Chloride Intracellular Channel 2 (CLIC2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-247
- Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CLIC2 protein is labelled with His tag.
- Purpose
- Recombinant Human Chloride Intracellular Channel Protein 2/CLIC2 (N-6His)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MSGLRPGTQV DPEIELFVKA GSDGESIGNC PFCQRLFMIL WLKGVKFNVT TVDMTRKPEE LKDLAPGTNP PFLVYNKELK TDFIKIEEFL EQTLAPPRYP HLSPKYKESF DVGCNLFAKF SAYIKNTQKE ANKNFEKSLL KEFKRLDDYL NTPLLDEIDP DSAEEPPVSR RLFLDGDQLT LADCSLLPKL NIIKVAAKKY RDFDIPAEFS GVWRYLHNAY AREEFTHTCP EDKEIENTYA NVAKQKS
- Characteristics
- Recombinant Human Chloride Intracellular Channel Protein 2/CLIC2 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Ser247) of Human CLIC2 fused with a His tag at the N-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product CLIC2 Protein
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Chloride Intracellular Channel 2 (CLIC2) (AA 1-247) protein (His tag)
CLIC2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Chloride Intracellular Channel 2 (CLIC2) (AA 1-247) protein (GST tag)CLIC2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Chloride Intracellular Channel 2 (CLIC2) (AA 1-247) protein (Strep Tag)Crystallography grade CLIC2 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Chloride Intracellular Channel 2 (CLIC2) protein (Myc-DYKDDDDK Tag)CLIC2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 100 mM NaCl, 1 mM DTT, 20 % Glycerol, pH 8.0.
- Preservative
- Dithiothreitol (DTT)
- Precaution of Use
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Storage
- -80 °C
- Storage Comment
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Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles. - Expiry Date
- 6 months
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- Target
- CLIC2 (Chloride Intracellular Channel 2 (CLIC2))
- Alternative Name
- Chloride Intracellular Channel Protein 2/CLIC2 (CLIC2 Products)
- Synonyms
- zgc:92762 Protein, CLIC2 Protein, CLIC2b Protein, MRXS32 Protein, XAP121 Protein, chloride intracellular channel 2 Protein, clic2 Protein, CLIC2 Protein, Clic2 Protein
- Sub Type
- Fusionprotein
- Background
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Chloride Intracellular Channel Protein 2 (CLIC2) is a critical component of all living cells, it regulates cellular traffic of Chloride ion and it can be inserted into membranes anf form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions, channel activity depends on the pH. CLIC2 is involved in regulating membrane potential and organic solute transport. CLIC2 modulates the activity of RYR2 and inhibits Calcium influx. CLIC2 can be detected in the adult brain, liver, lung, heart, stomach, spleen and testis. It is expressed in fetal liver and adult skeletal muscle. CLIC2 is a potential candidate for one of many diseases linked to Xq28.
Alternative Names: Chloride Intracellular Channel Protein 2, XAP121, CLIC2 - Molecular Weight
- 30.5 kDa
- UniProt
- O15247
- Pathways
- Negative Regulation of Transporter Activity
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