MCL-1 Protein (His tag)
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- Target See all MCL-1 (MCL1) Proteins
- MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This MCL-1 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Purification
- purified by chromatography
- Purity
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product MCL1 Protein
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Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) (AA 1-327) protein (His tag)
MCL1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) (AA 1-331) protein (Strep Tag)Crystallography grade MCL1 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) (AA 1-350) protein (Strep Tag)Crystallography grade MCL1 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) (AA 1-308), (partial) protein (His-SUMO Tag)MCL1 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)MCL1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Comment
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Synonyms: induced myeloid leukemia cell differentiation protein Mcl-1, BCL2L3, mcl1/EAT, myeloid cell leukemia sequence 1, Bcl-2-like protein 3
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/ml (determined by Bradford assay)
- Buffer
- 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, 20% glycerol, 2 mM DTT
- Storage
- 4 °C
- Storage Comment
- Avoid repeated freezing and thawing cycles.
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- Target
- MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))
- Alternative Name
- MCL1 (MCL1 Products)
- Synonyms
- BCL2L3 Protein, EAT Protein, MCL1-ES Protein, MCL1L Protein, MCL1S Protein, Mcl-1 Protein, TM Protein, bcl2-L-3 Protein, mcl1/EAT Protein, AW556805 Protein, mcl-1 Protein, fb72f02 Protein, wu:fb70a08 Protein, wu:fb72f02 Protein, zfMLP1 Protein, zfMcl-1a Protein, zgc:109835 Protein, zgc:109763 Protein, E3 Protein, E3-2 Protein, RNE3 Protein, RNU107 Protein, SNORA63A Protein, elF-4AII Protein, MCL1, BCL2 family apoptosis regulator Protein, myeloid cell leukemia sequence 1 Protein, MCL1, BCL2 family apoptosis regulator a Protein, MCL1, BCL2 family apoptosis regulator b Protein, small nucleolar RNA, H/ACA box 63 Protein, MCL1 Protein, Mcl1 Protein, mcl1a Protein, mcl1b Protein, SNORA63 Protein
- Background
- MCL1, also known as BCL2L3, belongs to the Bcl-2 family. MCL1 is involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. Recombinant human MCL1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques
- Molecular Weight
- 37.2 kDa (347aa), confirmed by MALDI-TOF
- NCBI Accession
- NP_068779
- Pathways
- MAPK Signaling
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