ATPase Inhibitory Factor 1 Protein (ATPIF1) (His tag)
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- Target See all ATPase Inhibitory Factor 1 (ATPIF1) Proteins
- ATPase Inhibitory Factor 1 (ATPIF1)
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This ATPase Inhibitory Factor 1 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Purification
- purified by chromatography
- Purity
- > 95 % by SDS - PAGE
- Top Product
- Discover our top product ATPIF1 Protein
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- Comment
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Synonyms: ATPase inhibitor mitochondrial, ATPI, ATPIP, IP, ATPase Inhibitory Factor 1
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, 50% glycerol, 2 mM DTT
- Storage
- 4 °C
- Storage Comment
- Avoid repeated freezing and thawing cycles.
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- Target
- ATPase Inhibitory Factor 1 (ATPIF1)
- Alternative Name
- ATPIF1 (ATPIF1 Products)
- Background
- ATPase inhibitory factor 1, also known as ATPIF1, binds to the C-terminal region of a beta subunit of the F1-ATPase at low pH values and, via interference of the beta and gamma subunit interaction, ATPIF1 regulates the activity of the F1 (the hydrophilic catalytic core), F0 (the membrane embedded protein channel) ATPase. The overexpression of ATPIF1 in several human carcinomas further supports its participation in oncogenesis and provides insight into the altered metabolism of cancer cells, which includes the reprogramming of energetic metabolism toward glycolysis. Recombinant human ATPIF1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
- Molecular Weight
- 12.2 kDa (106aa), confirmed by MALDI-TOF
- NCBI Accession
- NP_057395
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