CDK2AP2 Protein (His tag)
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- Target See all CDK2AP2 Proteins
- CDK2AP2 (Cyclin-Dependent Kinase 2 Associated Protein 2 (CDK2AP2))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CDK2AP2 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Purification
- purified by chromatography
- Purity
- > 95 % by SDS - PAGE
- Top Product
- Discover our top product CDK2AP2 Protein
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- Comment
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Synonyms: cyclin-dependent kinase 2 associated protein 2, DOC-1R, p14
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, 50% glycerol, 2 mM DTT
- Storage
- 4 °C
- Storage Comment
- Avoid repeated freezing and thawing cycles.
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- Target
- CDK2AP2 (Cyclin-Dependent Kinase 2 Associated Protein 2 (CDK2AP2))
- Alternative Name
- CDK2AP2 (CDK2AP2 Products)
- Synonyms
- DOC-1R Protein, p14 Protein, zgc:92182 Protein, 5830466O21Rik Protein, D19Ertd144e Protein, Doc-1r Protein, cyclin dependent kinase 2 associated protein 2 Protein, cyclin-dependent kinase 2 associated protein 2 Protein, CDK2-associated protein 2 Protein, CDK2AP2 Protein, cdk2ap2 Protein, Cdk2ap2 Protein
- Background
- CDK2AP2, also known as DOC-1R and p14, belongs to the CDK2AP family. CDK2-associated protein is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. CDK2AP2 is a regulator for self-renewal of mouse embryonic stem cells (mESCs) under permissive conditions, and cell survival during differentiation of the mESCs into terminally differentiated cell types. CDK2AP2 may be involved in the regulation of self-renewal of stem cells during early embryogenesis. Recombinant human CDK2AP2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
- Molecular Weight
- 15.5kDa (149aa), confirmed by MALDI-TOF
- NCBI Accession
- NP_005842
- Pathways
- PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA
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