Succinate Dehydrogenase Complex Assembly Factor 2 (Sdhaf2) protein (His tag)

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Protein Name
  • C14H11orf79
  • C11orf79
  • PGL2
  • SDH5
  • 0610038F07Rik
  • AA407634
  • AW049997
  • RGD1309216
  • wu:fj30e04
  • zgc:163000
  • succinate dehydrogenase complex assembly factor 2
  • SDHAF2
  • LOC100353725
  • Sdhaf2
  • sdhaf2
Origin
Human
4
1
1
1
1
Source
Escherichia coli (E. coli)
4
3
1
Protein Type
Recombinant
Purification tag / Conjugate
This Sdhaf2 protein is labelled with His tag.
Application
SDS-PAGE (SDS)
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Purification purified by chromatography
Purity > 90 % by SDS - PAGE
Background SDHAF2 is a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Defects in SDHAF2 are the cause of hereditary paragangliomas type 2 (PGL2), also known as familial non-chromaffin paragangliomas type 2. Paragangliomas refer to rare and mostly benign tumors that arise from any component of the neuroendocrine system. Recombinant human SDHAF2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Molecular Weight 19.0kDa (160aa), confirmed by MALDI-TOF
NCBI Accession NP_060311
Research Area Metabolism
Comment

Synonyms: Succinate dehydrogenase assembly factor 2, mitochondrial, C11orf79, PGL2, SDH5

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/ml (determined by Bradford assay)
Buffer 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, 30% glycerol, 1 MM DTT
Storage 4 °C
Storage Comment Avoid repeated freezing and thawing cycles.
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 image for Succinate Dehydrogenase Complex Assembly Factor 2 (Sdhaf2) protein (His tag) (ABIN1098508) Succinate Dehydrogenase Complex Assembly Factor 2 (Sdhaf2) protein (His tag)
Background publications Kunst, Rutten, de Mönnink, Hoefsloot, Timmers, Marres, Jansen, Kremer, Bayley, Cremers: "SDHAF2 (PGL2-SDH5) and hereditary head and neck paraganglioma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 2, pp. 247-54, 2011 (PubMed).

Starker, Delgado-Verdugo, Udelsman, Björklund, Carling: "Expression and somatic mutations of SDHAF2 (SDH5), a novel endocrine tumor suppressor gene in parathyroid tumors of primary hyperparathyroidism." in: Endocrine, Vol. 38, Issue 3, pp. 397-401, 2010 (PubMed).

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