PRKAB2 Protein (His tag)
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- Target See all PRKAB2 Proteins
- PRKAB2 (Protein Kinase, AMP-Activated, beta 2 Non-Catalytic Subunit (PRKAB2))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This PRKAB2 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Purity
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product PRKAB2 Protein
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- Comment
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Synonyms: 5'-AMP-activated protein kinase subunit beta-2
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.0 mg/ml (determined by Bradford assay)
- Buffer
- 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 2 M Urea
- Storage
- 4 °C
- Storage Comment
- Avoid repeated freezing and thawing cycles.
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- Target
- PRKAB2 (Protein Kinase, AMP-Activated, beta 2 Non-Catalytic Subunit (PRKAB2))
- Alternative Name
- PRKAB2 (PRKAB2 Products)
- Synonyms
- prkab2 Protein, MGC64365 Protein, PRKAB2 Protein, DKFZp469M1118 Protein, 5730553K21Rik Protein, AW049591 Protein, BB124140 Protein, protein kinase, AMP-activated, beta 2 non-catalytic subunit L homeolog Protein, protein kinase AMP-activated non-catalytic subunit beta 2 Protein, protein kinase, AMP-activated, beta 2 non-catalytic subunit Protein, prkab2.L Protein, PRKAB2 Protein, prkab2 Protein, Prkab2 Protein
- Background
- PRKAB2 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. PRKAB2 may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Recombinant human PRKAB2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
- Molecular Weight
- 32.8 kDa(296aa)
- NCBI Accession
- NP_005390
- Pathways
- AMPK Signaling, Warburg Effect
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