LYN Protein (His tag)
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- Target See all LYN Proteins
- LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This LYN protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Purity
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product LYN Protein
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- Comment
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Synonyms: Tyrosine-protein kinase Lyn, JTK8, p53Lyn, p56Lyn
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M urea, 10% glycerol
- Storage
- 4 °C
- Storage Comment
- Avoid repeated freezing and thawing cycles.
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- Target
- LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
- Alternative Name
- LYN (LYN Products)
- Synonyms
- JTK8 Protein, p53Lyn Protein, p56Lyn Protein, lyn Protein, LYN Protein, AA407514 Protein, Hck-2 Protein, jtk8 Protein, lyn-A Protein, CH73-38P6.3 Protein, zgc:92124 Protein, LYN proto-oncogene, Src family tyrosine kinase Protein, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog Protein, tyrosine-protein kinase Lyn Protein, LYN proto-oncogene, Src family tyrosine kinase L homeolog Protein, LYN Protein, lyn Protein, Lyn Protein, LOC100593961 Protein, lyn.L Protein
- Background
- Tyrosine-protein kinase Lyn, also known as LYN, is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues. This protein is Involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents. It Induces SAPK by a MKK7- and MEKK1-dependent mechanism. The LYN -> MEKK1 -> MKK7 -> SAPK pathway is functional in the induction of apoptosis by genotoxic agents. Recombinant human LYN protein, fused to His-tag at N-terminus, was expressed in E.coli.
- Molecular Weight
- 61.0 kDa (535aa)
- NCBI Accession
- NP_002341
- Pathways
- Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling, Integrin Complex, BCR Signaling
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