IL-1 beta Protein (AA 117-269)
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- Target See all IL-1 beta (IL1B) Proteins
- IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 117-269
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Application
- SDS-PAGE (SDS)
- Specificity
- Binds to human IL-1R.
- Cross-Reactivity
- Human
- Characteristics
- Human IL-1beta (aa 117-269) is untagged.
- Purity
- >95 % (SDS-PAGE)
- Endotoxin Level
- <0.1EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product IL1B Protein
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Interleukin 1, beta (IL1B) (AA 117-269) protein (His-Avi Tag)
IL1B Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by SEC-HPLC
Interleukin 1, beta (IL1B) (AA 117-269) protein (His-Avi Tag,Biotin)IL1B Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 1, beta (IL1B) (AA 1-269) protein (GST tag)IL1B Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 1, beta (IL1B) (AA 115-267) protein (His tag)IL1B Origin: Pig Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Interleukin 1, beta (IL1B) (AA 116-268) protein (His tag)IL1B Origin: Horse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Interleukin 1, beta (IL1B) (AA 114-266) protein (His tag)IL1B Origin: Goat Host: Escherichia coli (E. coli) Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
Interleukin 1, beta (IL1B) (AA 115-266) protein (His tag)IL1B Origin: Dog Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Interleukin 1, beta (IL1B) (AA 106-267) protein (His tag)IL1B Origin: Chicken Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Interleukin 1, beta (IL1B) (AA 113-271) protein (His tag)IL1B Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % by SDS - PAGE SDS
Interleukin 1, beta (IL1B) (AA 170-269) protein (GST tag)IL1B Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Activates the NF-kappaB with an ED50 of <5ng/ml.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with 100 μL sterile water.
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Expiry Date
- 6 months
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- Target
- IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))
- Alternative Name
- IL-1beta (IL1B Products)
- Synonyms
- IL-1 Protein, IL1-BETA Protein, IL1F2 Protein, IL-1BETA Protein, IL1beta Protein, il1-b Protein, zgc:111873 Protein, IL-1B Protein, IL-1beta Protein, Il-1b Protein, IL1B Protein, IL-1 beta Protein, IL-1b Protein, interleukin 1 beta Protein, interleukin 1, beta Protein, IL1B Protein, il1b Protein, Il1b Protein
- Background
- IL-1beta is produced by activated macrophages. IL-1beta stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1beta belongs to the IL-1 family of proteins that are involved in the inflammatory response. IL-1beta in most situations requires the inflammasome complex to be cleaved and secreted.
- Molecular Weight
- ~17kDa (SDS-PAGE)
- UniProt
- P01584
- Pathways
- NF-kappaB Signaling, Interferon-gamma Pathway, TLR Signaling, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Autophagy, Cancer Immune Checkpoints, Inflammasome
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