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ANGPTL4 Protein (AA 1-410) (DYKDDDDK Tag)

ANGPTL4 Origin: Mouse Host: COS-7 Cells Recombinant >90 % (SDS-PAGE) SDS Active
Catalog No. ABIN1344082
  • Target See all ANGPTL4 Proteins
    ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 1-410
    Origin
    • 11
    • 7
    • 3
    • 3
    • 3
    • 1
    Mouse
    Source
    • 11
    • 8
    • 3
    • 2
    • 2
    • 2
    COS-7 Cells
    Purification tag / Conjugate
    This ANGPTL4 protein is labelled with DYKDDDDK Tag.
    Application
    SDS-PAGE (SDS)
    Cross-Reactivity
    Mouse (Murine)
    Characteristics
    Mouse ANGPTL4 (aa 1-410) is fused at the C-terminus to a FLAG®-tag.
    Purity
    >90 % (SDS-PAGE)
    Sterility
    0.2 μm filtered
    Endotoxin Level
    <0.1EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product ANGPTL4 Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Comment

    Activates ERK phosphorylation in THP-1 cells.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    0.2μm-filtered solution in PBS.
    Storage
    4 °C,-20 °C
    Storage Comment
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Working aliquots are stable for up to 3 months when stored at -20°C.
    Expiry Date
    3 months
  • Target
    ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))
    Alternative Name
    ANGPTL4 (ANGPTL4 Products)
    Synonyms
    ANGPTL2 Protein, ARP4 Protein, FIAF Protein, HFARP Protein, NL2 Protein, PGAR Protein, pp1158 Protein, Arp4 Protein, Bk89 Protein, Fiaf Protein, Hfarp Protein, Ng27 Protein, Pgar Protein, Pgarg Protein, Pp1158 Protein, ANGPTL4 Protein, fiaf Protein, im:7144703 Protein, si:rp71-39b20.7 Protein, angiopoietin like 4 Protein, angiopoietin-like 4 Protein, ANGPTL4 Protein, Angptl4 Protein, angptl4 Protein
    Background
    ANGPTL4 (Angiopoietin-like protein 4) mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorigenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.
    Molecular Weight
    ~50kDa (SDS-PAGE)
    UniProt
    Q9Z1P8
    Pathways
    Regulation of Lipid Metabolism by PPARalpha
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