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IL-2 Protein

IL2 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 98 % by SDS-PAGE. Visualized by silver stain Active
Catalog No. ABIN1589645
  • Target See all IL-2 (IL2) Proteins
    IL-2 (IL2) (Interleukin 2 (IL2))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 32
    • 17
    • 8
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 41
    • 25
    • 22
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Sequence
    MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFCQSII STLHYKDPAA NKARKEAELA AATAEQ
    Characteristics
    Length (AA): 156
    Chromosomal location: 4q26-q27
    The ED50 as determined by the dose-dependent stimulation of proliferation of murine D10G4.1 cells is in the range of 0.1-0.5 ng/mL.
    Purity
    > 98 % by SDS-PAGE. Visualized by silver stain
    Endotoxin Level
    < 0.1 ng per µg of IL-2
    Top Product
    Discover our top product IL2 Protein
  • Comment

    Cytokines & Growth Factors

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    The lyophilized IL-2 should be reconstituted in 50 mM acetic acid to a concentration not less than 100 μg/mL. This solution can be diluted into other buffered solutions or stored at -20 °C for future use.
    Buffer
    50 mM acetic acid
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    0 °C
    Storage Comment
    The lyophilized IL-2, though stable at room temperature, is best stored desiccated below 0 °C. Reconstituted IL-2 should be stored in workingaliquots at -20 °C.
  • Haustein, Ramer, Linnebacher, Manda, Hinz: "Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1." in: Biochemical pharmacology, Vol. 92, Issue 2, pp. 312-25, (2014) (PubMed).

  • Target
    IL-2 (IL2) (Interleukin 2 (IL2))
    Alternative Name
    IL-2 (IL2 Products)
    Synonyms
    IL2 Protein, IL-2 Protein, il2 Protein, TCGF Protein, lymphokine Protein, Il-2 Protein, POIL2 Protein, interleukin 2 Protein, interleukin-15 Protein, IL2 Protein, il2 Protein, LOC100303688 Protein, Il2 Protein
    Background
    IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant human IL-2 (modified at the C-terminal end) is a 15.5 kDa protein, containing 156 amino acid residues including one intrachain disulfide bond.
    Synonyms: IL2, IL-2, TCGF, lymphokine
    Molecular Weight
    15.5 kDa
    NCBI Accession
    NP_000577, NM_000586
    UniProt
    P60568
    Pathways
    JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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