ESAM Protein (His tag)

Catalog No. ABIN1589731

Product Details

Target: ESAM (Endothelial Cell Adhesion Molecule (ESAM))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This ESAM protein is labelled with His tag.

Sequence: ISLPGPLVTN LLRFLFLGLS ALAPPSRAQL QLHLPANRLQ AVEGGEVVLP AWYTLHGEVS SSQPWEVPFV MWFFKQKEKE DQVLSYINGV TTSKPGVSLV YSMPSRNLSL RLEGLQEKDS GPYSCSVNVQ DKQGKSRGHS IKTLELNVLV PPAPPSCRLQ GVPHVGANVT LSCQSPRSKP AVQYQWDRQL PSFQTFFAPA LDVIRGSLSL TNLSSSMAGV YVCKAHNEVG TAQCNVTLEV STGPGARSHH HHHH

Characteristics: Chromosomal location: 11q24.2

Purity: > 95 % by SDS-PAGE. Visualized by silver stain

Application Details

Application Notes: No biological data available at the moment.

Comment:

Cytokines & Growth Factors

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Human ESAM should be reconstituted in sterile water to a concentration of 0.1 mg/mL. This solution can be diluted in water or other buffer solutions or stored at -20 °C.

Buffer: PBS

Storage: 0 °C

Storage Comment: The lyophilized human ESAM, though stable at room temperature, is best stored desiccated below 0 °C.

Target Details

Target: ESAM (Endothelial Cell Adhesion Molecule (ESAM))

Alternative Name: ESAM (ESAM Products)

Synonyms: ESAM Protein, sc:d0254 Protein, W117m Protein, 2310008D05Rik Protein, Esam1 Protein, endothelial cell adhesion molecule Protein, endothelial cell adhesion molecule a Protein, endothelial cell-specific adhesion molecule Protein, ESAM Protein, esama Protein, Esam Protein

Background: Endothelial cell selective adhesion molecule (ESAM) is a 55 kDa type I transmembrane glycoprotein that belongs to the JAM family of immunoglobulin superfamily molecules. Human ESAM is synthesized as a 390 amino acid (aa) protein composed of a 29 aa signal peptide, a 216 aa extracellular region, a putative 26 aa transmembrane segment, and a 119 aa cytoplasmic domain. The extracellular region contains one V-type and one C2-type Ig domain and is involved in hemophilic adhesion. In the cytoplasmic domain, there is a docking site for the multifunctional adaptor protein MAGI1. The extracellular region of human ESAM shows 90 %, 74%, 69% and 67% aa identity with monkey, canine, mouse and rat extracellular ESAM, respectively. ESAM is expressed on endothelial cells, activated platelets and megakaryocytes, and can be found associated with cell to cell junctions. Whether ESAM is restricted to a particular junctional type is not clear. ESAM deficient mice have no defect in vascularization but do have reduced angiogenic potential. This may be due to a decreased migratory response to FGF2. Soluble ESAM is fused to a C-terminal His-tag (6x His).
Synonyms: ESAM, W117m

Molecular Weight: 27.8 kDa

NCBI Accession: NM_138961, NP_620411

UniProt: Q96AP7