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IL13 Receptor alpha 1 Protein (C-Term, Extracellular Domain)

IL13RA1 Origin: Human Host: HEK-293T Cells Recombinant > 98 %, as determined by SDS-PAGE and HPLC Active
Catalog No. ABIN1684619
  • Target See all IL13 Receptor alpha 1 (IL13RA1) Proteins
    IL13 Receptor alpha 1 (IL13RA1) (Interleukin 13 Receptor, alpha 1 (IL13RA1))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    C-Term, Extracellular Domain
    Origin
    • 16
    • 11
    • 1
    • 1
    Human
    Source
    • 14
    • 4
    • 4
    • 3
    • 2
    • 1
    HEK-293T Cells
    Specificity
    Optimized DNA sequence encoding extracellular domain of human IL-13 receptor alpha 1 including a C terminal His tag and Fc tag was expressed in HEK293 cells.
    Characteristics
    Recombinant IL-13RA1 is a homodimer protein consisting of two 570 amino acid residue subunits, due to glycosylation migrates as an approximately 90kDa protein on SDS-PAGE.
    Purity
    > 98 %, as determined by SDS-PAGE and HPLC
    Sterility
    0.2 μm filtered
    Endotoxin Level
    Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).
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    Discover our top product IL13RA1 Protein
  • Comment

    The activity was tested by immobilized recombinant human IL-13 (4 µg/mL) ability to bind recombinant human IL-13RA1 with a linear range of 0.1-2.5 µg/mL in functional ELISA.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS solution, pH7.2
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    -20 °C
    Storage Comment
    The lyophilized protein is stable for at least years from date of receipt at -20 °C. Upon reconstitution, this cytokine can be stored in working aliquots at - 8 °C for one month, or at -20 °C for six months, with a carrier protein without detectable loss of activity.
    Expiry Date
    12-24 months
  • Target
    IL13 Receptor alpha 1 (IL13RA1) (Interleukin 13 Receptor, alpha 1 (IL13RA1))
    Alternative Name
    IL13RA1 (IL13RA1 Products)
    Synonyms
    CD213A2 Protein, CT19 Protein, IL-13R Protein, IL13BP Protein, CD213A1 Protein, IL-13Ra Protein, NR4 Protein, AI882074 Protein, CD213a1 Protein, IL-13r[a] Protein, Il13ra Protein, IL13RA1 Protein, il-13ra1 Protein, si:ch211-150g2.2 Protein, interleukin 13 receptor subunit alpha 2 Protein, interleukin 13 receptor subunit alpha 1 Protein, interleukin 13 receptor, alpha 1 Protein, interleukin 13 receptor, alpha 1-like Protein, IL13RA2 Protein, IL13RA1 Protein, Il13ra1 Protein, il13ra1 Protein, LOC100360218 Protein
    Background
    Thrombopoietin TPO, known also as TSF (thrombopoiesis stimulating factor), for mediator substances that function as natural stimulators of megakaryocytopoiesis and thus, promote the differentiation of platelets. TPO stimulates an increase in the sizes and numbers of megakaryocytes. It also increases the number of small acetyl-cholinesterase positive cells that are early precursor cells of the megakaryocytic lineage. TPO is a protein of 332 amino acids that shows significant homology with Epo (erythropoietin) in its N-terminal domain. A comparison of human and porcine TPO sequences shows 83 % identity between the erythropoietin-like domains but only 67 % between the C-terminal domains.
    UniProt
    P78552
    Pathways
    JAK-STAT Signaling, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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