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CD200 Protein (CD200) (C-Term, Extracellular Domain)

CD200 Origin: Mouse Host: HEK-293T Cells Recombinant > 98 %, as determined by SDS-PAGE and HPLC Active
Catalog No. ABIN1684663
  • Target See all CD200 Proteins
    CD200
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    C-Term, Extracellular Domain
    Origin
    • 23
    • 7
    • 2
    • 1
    Mouse
    Source
    • 16
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    HEK-293T Cells
    Specificity
    Optimized DNA sequence encoding extracellular domain of Mouse CD200 including a C-terminal 6His tag was expressed in HEK293 cells.
    Characteristics
    Recombinant Mouse CD200 is a monomer protein consisting of13 amino acid residue subunits, due to glycosylation migrates as an approximately 40-45kDa protein on SDS-PAGE.
    Purity
    > 98 %, as determined by SDS-PAGE and HPLC
    Sterility
    0.2 μm filtered
    Endotoxin Level
    Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).
    Top Product
    Discover our top product CD200 Protein
  • Comment

    The activity was tested by the ability of immobilized recombinant mouse CD200 (1 µg/mL,100 µL/well) to bind mouse CD200R1 with a linear range of 1-200 ng/mL

    Restrictions
    For Research Use only
  • Buffer
    PBS solution, pH7.2
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    -20 °C
    Storage Comment
    The lyophilized antibody is stable for at least 1 year from date of receipt at -20 °C. Upon reconstitution, this antibody can be stored in working aliquots at - 8 °C for one month, or at -20 °C for six months without detectable loss of activity.
    Expiry Date
    12 months
  • Target
    CD200
    Alternative Name
    CD200 (CD200 Products)
    Synonyms
    MOX1 Protein, MOX2 Protein, MRC Protein, OX-2 Protein, CD200 Protein, Cspmo2 Protein, MRCOX2 Protein, Mox2 Protein, DKFZp459C0716 Protein, OX2 Protein, CD200 molecule Protein, Cd200 molecule Protein, CD200 antigen Protein, CD200 Protein, Cd200 Protein
    Background
    CD7 is a 40-kD member of the Ig gene superfamily that is expressed on a major subset of human peripheral T lymphocytes and NK cells. CD7 can complex with CD3 and CD45 molecules, and CD7 signaling involves both protein kinase C and protein tyrosine kinase. CD7 has been shown to be a functional signal-transducing molecule on resting NK cells. Although the function of CD7 is unknown, studies suggest that CD7 may be involved in T and NK cell activation and/or adhesion. In TCRbeta T cells, cross-linking of CD7 leads to rapid increases in intracellular calcium concentrations, induces CD7 cytoplasmic domain association with phosphotidylinositol-3-kinase, synergizes with submitogenic amounts of CD3 mAbs to induce T cell activation, modulates T cell adhesion, and increases T cell IL-2 production and IL-2 receptor expression. In TCR T cells, cross-linking of CD7 leads to cell activation and induction of TNF-a, TNF-b, and granulocyte-macrophage CSF mRNA.
    UniProt
    O54901
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