Epithelial Mitogen Homolog (Mouse) (EPGN) (Active) Protein

Details for Product No. ABIN1686210, Supplier: Log in to see
Protein Name
  • ALGV3072
  • EPG
  • PRO9904
  • 2310069M11Rik
  • epigen
  • RGD1560084
  • epithelial mitogen
  • epithelial mitogen homolog (mouse)
  • EPGN
  • Epgn
Origin
Human
18
1
1
Source
Escherichia coli (E. coli)
12
2
1
1
1
1
Protein Type
Recombinant
Biological Activity
Active
Application
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
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Purity ≥98 % by SDS-PAGE
≥98 % by HPLC
Sterility Sterile filtered
Endotoxin Level <0.1 ng/μg
ProductDetails: Biological Activity Comment Determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells. The expected ED₅₀ for this effect is 150-300 ng/ml.
Background EPGN is an EGF-related polypeptide growth factor that signals through the ErbB receptor-1. EPGN is produced in numerous tissues, including the testis, liver, heart and in certain tumor cells. EPGN is mitogenic for fibroblasts and epithelial cells. Human EPGN is originally synthesized as a glycosylated 14.7 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a mature soluble sequence. Recombinant Human epigen produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 72 amino acids and having a molecular mass of 7.9 kDa. Epigen is purified by proprietary chromatographic techniques.

Alternative Names: EPG, Epigen, PRO9904, ALGV3072, FLJ75542, EPGN, Epithelial mitogen.
Molecular Weight 7.9 kDa
Gene ID 255324
UniProt Q6UW88
Pathways RTK Signaling, EGFR Signaling Pathway
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in sterile dH₂O not less than 100 μg/mL.For long term storage it is recommended to add a carrier protein (0.1 % HSA or BSA).
Buffer Sterile filtered and lyophilized from 20 mM PBS buffer pH -7.4 containing 130 mM sodium chloride
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Expiry Date 12 months
Product cited in: Tai, Bilousova, Jungbauer, Roeske, Youmans, Yu, Poon, Cornwell, Miller, Vinters, Van Eldik, Fardo, Estus, Bu, Gylys, Ladu: "Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples." in: The Journal of biological chemistry, Vol. 288, Issue 8, pp. 5914-26, 2013 (PubMed).

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