AHSA1 Protein (His tag)

Catalog No. ABIN1686742

Product Details

Target: AHSA1 (Activator of HSP90 ATPase Activity 1 (AHSA1))

Protein Type: Recombinant

Origin: Saccharomyces cerevisiae

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This AHSA1 protein is labelled with His tag.

Application: Western Blotting (WB), SDS-PAGE (SDS), Functional Studies (Func)

Sequence: MGHHHHHHMV VNNPNNWHWV DKNCIGWAKE YFKQKLVGVE AGSVKDKKYA KIKSVSSIEG DCEVNQRKGK VISLFDLKIT VLIEGHVDSK DGSALPFEGS INVPEVAFDS EASSYQFDIS IFKETSELSE AKPLIRSELL PKLRQIFQQF GKDLLATHGN DIQVPESQVK SNYTRGNQKS SFTEIKDSAS KPKKNALPSS TSTSAPVSST NKVPQNGSGN STSIYLEPTF NVPSSELYET FLDKQRILAW TRSAQFFNSG PKLETKEKFE LFGGNVISEL VSCEKDKKLV FHWKLKDWSA PFNSTIEMTF HESQEFHETK LQVKWTGIPV GEEDRVRANF EEYYVRSIKL TFGFGAVL

Specificity: ~405 kDa

Purification: Affinity Purified

Purity: >90%

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

This product has been certified >90% pure using SDS - PAGE analysis.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: 12.5 mM Hepes buffer pH 7.2, 10 mM NaCl, 50 % glycerol

Storage: -20 °C

Target Details

Target: AHSA1 (Activator of HSP90 ATPase Activity 1 (AHSA1))

Alternative Name: Aha1 (AHSA1 Products)

Synonyms: ahsa1 Protein, MGC52884 Protein, MGC132147 Protein, MGC80312 Protein, AHSA1 Protein, MGC89589 Protein, wu:fb83b05 Protein, zgc:136821 Protein, zgc:56075 Protein, AHA1 Protein, C14orf3 Protein, p38 Protein, BC023857 Protein, AHA1, activator of heat shock 90kDa protein ATPase homolog 1 S homeolog Protein, activator of Hsp90 ATPase activity 1 Protein, AHA1, activator of heat shock 90kDa protein ATPase homolog 1 L homeolog Protein, activator of HSP90 ATPase activity 1 Protein, AHA1, activator of heat shock 90kDa protein ATPase homolog 1 Protein, AHA1, activator of heat shock protein ATPase homolog 1a Protein, AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) Protein, AHA1, activator of heat shock protein ATPase 1 Protein, ahsa1.S Protein, AHSA1 Protein, ahsa1.L Protein, ahsa1 Protein, ahsa1a Protein, Ahsa1 Protein

Background: Aha1 is a member of the HSP90 cochaperone family, and is thought to stimulate HSP90 ATPase activity by competing with p23 and other co-chaperones for HSP90 binding (1, 2). It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G) (3). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors (4).

Molecular Weight: Approx. 40.5 kDa

Gene ID: 851800

NCBI Accession: NM_001180522

UniProt: Q12449