CDNF Protein (AA 25-187) (His tag)

Catalog No. ABIN1691490

Product Details

Target: CDNF (Cerebral Dopamine Neurotrophic Factor (CDNF))

Protein Type: Recombinant

Protein Characteristics: AA 25-187

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This CDNF protein is labelled with His tag.

Purpose: Recombinant Human Cerebral Dopamine Neurotrophic Factor/CDNF/ARMETL1 (C-6His)

Sequence: QGQEAGGRPG ADCEVCKEFL NRFYKSLIDR GVNFSLDTIE KELISFCLDT KGKENRLCYY LGATKDAATK ILSEVTRPMS VHMPAMKICE KLKKLDSQIC ELKYEKTLDL ASVDLRKMRV AELKQILHSW GEECRACAEK TDYVNLIQEL APKYAATHPK TELHHHHHH

Characteristics: Recombinant Human Cerebral dopamine neurotrophic factor/CDNF is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Gln25­Leu187) of Human CDNF fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 5 months

Target Details

Target: CDNF (Cerebral Dopamine Neurotrophic Factor (CDNF))

Alternative Name: CDNF (CDNF Products)

Synonyms: ARMETL1 Protein, 9330140G23 Protein, Armetl1 Protein, cerebral dopamine neurotrophic factor Protein, CDNF Protein, Cdnf Protein

Sub Type: Fusionprotein

Background: Erebral Dopamine Neurotrophic Factor (CDNF), also known as ARMETL1 (ARMET-like protein 1), is a secreted protein with eight conserved cysteine residues.It is belongs to the ARMET family. CDNF/ARMETL1 is a evolutionary conserved protein which can protect and restore the function of dopaminergic neurons in the rat model of Parkinson's disease, suggesting that CDNF might be beneficial for the treatment of Parkinson's disease. CDNF is widely expressed in neurons in several brain regions including cerebral cortex, hippocampus, substantia nigra, striatum and cerebellum. Human CDNF is glycosylated and secreted from transiently transfected cells. CDNF promotes the survival, growth, and function of dopamine-specific neurons and is expressed in brain regions that undergo cocaine-induced neuroplasticity.
Alternative Names: Cerebral dopamine neurotrophic factor, ARMET-like protein 1, Conserved dopamine neurotrophic factor, ARMETL1

Molecular Weight: 21.7 kDa

UniProt: Q49AH0