C1QBP Protein (AA 74-282) (His tag)

Catalog No. ABIN1692169

Product Details

Target: C1QBP (Complement Component 1, Q Subcomponent Binding Protein (C1QBP))

Protein Type: Recombinant

Protein Characteristics: AA 74-282

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This C1QBP protein is labelled with His tag.

Purpose: Recombinant Human C1QBP/HABP1 (C-6His)

Sequence: MLHTDGDKAF VDFLSDEIKE ERKIQKHKTL PKMSGGWELE LNGTEAKLVR KVAGEKITVT FNINNSIPPT FDGEEEPSQG QKVEEQEPEL TSTPNFVVEV IKNDDGKKAL VLDCHYPEDE VGQEDEAESD IFSIREVSFQ STGESEWKDT NYTLNTDSLD WALYDHLMDF LADRGVDNTF ADELVELSTA LEHQEYITFL EDLKSFVKSQ LEHHHHHH

Characteristics:

Recombinant Human C1QBP/HABP1 (C-6His)

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris, 20 % Glycerol, 1 mM DTT, pH 7.5.

Preservative: Dithiothreitol (DTT)

Precaution of Use: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: -80 °C

Storage Comment: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: C1QBP (Complement Component 1, Q Subcomponent Binding Protein (C1QBP))

Alternative Name: Complement Component 1 Q Subcomponent-Binding Protein Mitochondrial/C1QBP (C1QBP Products)

Synonyms: SF2 Protein, X38k Protein, gC1qR Protein, C1QBP Protein, GC1QBP Protein, HABP1 Protein, SF2p32 Protein, gC1Q-R Protein, p32 Protein, AA407365 Protein, AA986492 Protein, D11Wsu182e Protein, P32 Protein, gC1qBP Protein, Habp1 Protein, complement C1q binding protein Protein, complement component 1, q subcomponent binding protein S homeolog Protein, complement component 1, q subcomponent binding protein Protein, C1QBP Protein, c1qbp.S Protein, LOC100227158 Protein, C1qbp Protein

Background: Recombinant Human Complement Component 1 Q Subcomponent-Binding Protein Mitochondrial/C1QBP is produced with our E. coli expression system. The target protein is expressed with sequence (Leu74-Gln282) of Human C1QBP fused with a 6His tag at the C-terminus.
Complement Component 1Q Subcomponent-Binding Protein (C1QBP) is a nucleus protein that belongs to the MAM33 family. C1QBP is known to bind to the globular heads of C1q molecules and inhibit C1 activation. Mitochondrial C1QBP is a critical mediator of p14ARF-induced apoptosis. C1QBP functions as a chemotactic factor for immature dendritic cells, and migration is mediated through ligation of both C1QBP and cC1qR/CR. C1QBP overexpression successfully blocks mRNA accumulation from the adenovirus major late transcription unit (MLTU) and stimulates RNA polymerase II carboxy-terminal domain phosphorylation in virus-infected cells.

Molecular Weight: 24.9 kDa

UniProt: Q07021

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly