CD70 Protein (AA 45-193) (Fc Tag)

Catalog No. ABIN1945394

Product Details

Target: CD70 (CD70 Molecule (CD70))

Protein Type: Recombinant

Protein Characteristics: AA 45-193

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This CD70 protein is labelled with Fc Tag.

Purpose: Recombinant Human CD27 Ligand/TNFSF7/CD70 (C-Fc)

Sequence: QQQLPLESLG WDVAELQLNH TGPQQDPRLY WQGGPALGRS FLHGPELDKG QLRIHRDGIY MVHIQVTLAI CSSTTASRHH PTTLAVGICS PASRSISLLR LSFHQGCTIA SQRLTPLARG DTLCTNLTGT LLPSRNTDET FFGVQWVRPV DDIEGRMDEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSREE MTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK

Characteristics: Recombinant Human TNFSF7/CD70 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Gln45­Pro193 ) of Human TNFSF7/CD70 fused with a FC tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CD70 (CD70 Molecule (CD70))

Alternative Name: TNFSF7-CD70 (CD70 Products)

Synonyms: CD27LG Protein, Cd27l Protein, Tnfsf7 Protein, CD27L Protein, TNFSF7 Protein, CD70 antigen Protein, CD70 molecule Protein, Cd70 molecule Protein, Cd70 Protein, CD70 Protein

Background: The CD70 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

Molecular Weight: 43.6 kDa

UniProt: P32970

Pathways: Cancer Immune Checkpoints