Transglutaminase 2 Protein (AA 2-686) (His tag)

Catalog No. ABIN1945408

Product Details

Target: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Protein Type: Recombinant

Protein Characteristics: AA 2-686

Origin: Mouse

Source: Human Cells

Purification tag / Conjugate: This Transglutaminase 2 protein is labelled with His tag.

Purpose: Recombinant Mouse Transglutaminase 2/TGM2 (C-6His)

Sequence: AEELLLERCD LEIQANGRDH HTADLCQEKL VLRRGQRFRL TLYFEGRGYE ASVDSLTFGA VTGPDPSEEA GTKARFSLSD NVEEGSWSAS VLDQQDNVLS LQLCTPANAP IGLYRLSLEA STGYQGSSFV LGHFILLYNA WCPADDVYLD SEEERREYVL TQQGFIYQGS VKFIKSVPWN FGQFEDGILD TCLMLLDMNP KFLKNRSRDC SRRSSPIYVG RVVSAMVNCN DDQGVLLGRW DNNYGDGISP MAWIGSVDIL RRWKEHGCQQ VKYGQCWVFA AVACTVLRCL GIPTRVVTNY NSAHDQNSNL LIEYFRNEFG ELESNKSEMI WNFHCWVESW MTRPDLQPGY EGWQAIDPTP QEKSEGTYCC GPVSVRAIKE GDLSTKYDAP FVFAEVNADV VDWIRQEDGS VLKSINRSLV VGQKISTKSV GRDDREDITH TYKYPEGSPE EREVFTKANH LNKLAEKEET GVAMRIRVGD SMSMGNDFDV FAHIGNDTSE TRECRLLLCA RTVSYNGVLG PECGTEDINL TLDPYSENSI PLRILYEKYS GCLTESNLIK VRGLLIEPAA NSYLLAERDL YLENPEIKIR VLGEPKQNRK LVAEVSLKNP LSDPLYDCIF TVEGAGLTKE QKSVEVSDPV PAGDLVKARV DLFPTDIGLH KLVVNFQCDK LKSVKGYRNV IIGPAVDHHH HHH

Characteristics: Recombinant Mouse Protein-glutamine gamma-glutamyltransferase 2/TGM2 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (AA 2-686) of Mouse TGM2 fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl,150 mM NaCl,20 % Glycerol, pH 7.5.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: -80 °C

Storage Comment: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Alternative Name: Protein-Glutamine gamma-Glutamyltransferase 2/TGM2 (TGM2 Products)

Synonyms: G-ALPHA-h Protein, GNAH Protein, TG2 Protein, TGC Protein, tgm2 Protein, zgc:101081 Protein, TgaseII Protein, TGM2 Protein, fc12b04 Protein, wu:fc12b04 Protein, zgc:136700 Protein, TGL2 Protein, G[a]h Protein, TGase2 Protein, tTG Protein, tTGas Protein, transglutaminase 2 Protein, transglutaminase 2, C polypeptide A Protein, transglutaminase 2b Protein, transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) Protein, transglutaminase 2, C polypeptide Protein, TGM2 Protein, tgm2a Protein, Tgm2 Protein, tgm2b Protein

Background: Protein-glutamine gamma-glutamyltransferase 2 (TGM2) is a 78-kDa, calcium dependent enzyme,It belongs to the transglutaminase superfamily and transglutaminase family. The protein encoded by this TGM2 gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. TGM2 is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 78 kDa

UniProt: P21981

Pathways: Tube Formation, Thromboxane A2 Receptor Signaling