Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1) (AA 1-152) (Active) Protein

Details for Product No. ABIN1981648, Supplier: Log in to see
Protein Name
  • AWD
  • GAAD
  • NB
  • NBS
  • NDKA
  • NDPK-A
  • NDPKA
  • NM23
  • NM23-H1
  • AL024257
  • NM23-M1
  • NM23A
  • NDPK-Z1
  • NM23-B
  • NM23-Z1
  • ndpkz1
  • nm23b
  • nme1
  • nme2
  • nme2b1
  • NME1
  • NME1-NME2
  • NM23-C1
  • ndpk-b
  • ndpkb
  • nm23-h2
  • nm23ndk
  • puf
  • NBR-A
  • NBR-B
  • NME1-1
  • nm23ndk-a
  • NDK I
  • NDPK I
  • T30A10.80
  • T30A10_80
  • NDP kinase I
  • NME/NM23 nucleoside diphosphate kinase 1
  • NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 1
  • non-metastatic cells 1, protein (NM23A) expressed in
  • NME/NM23 nucleoside diphosphate kinase 2 S homeolog
  • NME/NM23 nucleoside diphosphate kinase 2 L homeolog
  • nucleoside diphosphate kinase
  • nucleoside diphosphate kinase 1
  • NME1
  • Nme1
  • nme2b.1
  • nme2.S
  • nme2.L
  • LOC547870
  • NDPK1
  • LOC107790563
Protein Characteristics
AA 1-152
8
7
3
2
2
2
2
2
1
1
1
Origin
Human
21
3
2
1
1
1
1
1
1
1
Source
Escherichia coli (E. coli)
20
9
2
2
Protein Type
Recombinant
Biological Activity
Active
Application
SDS-PAGE (SDS)
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Sequence MANCERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVGLKF MQASEDLLKE HYVDLKDRPF FAGLVKYMHS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRNIIHGS DSVESAEKEI GLWFHPEELV DYTSCAQNWI YE
Characteristics Molecule Information: 17.1 kDa (152 aa, 1-152 aa)
Purity ≥95 % by SDS-PAGE
Endotoxin Level < 1.0 EU per 1 μg of protein (determined by LAL method)
Biological Activity Comment Specific activity is > 180 unit/ml, in which one unit will convert 1.0 μmole each of TDP and ATP to TTP and ADP per minute at pH 7.6 at 25°C in a coupled system with PK/LDH.
Unit Definition One unit will convert 1.0 μmole each of TDP and ATP to TTP and ADP per minute at pH 7.6 at 25°C in a coupled system with PK/LDH.
Background Non-metastatic cells 1 (NME1), also known as NM23-H1, originally identified as a candidate metastasis suppressor gene. NME1 is expressed in different tumor types where their levels have been alternatively associated with reduced or increased metastatic potential. Reductions in NME1 expression have been significantly associated with aggressive behavior in melanoma, breast, colon, and gastric carcinomas. On the contrary, high levels of NME1 gene expression are noted in the advanced stage of thyroid carcinomas. Recombinant human NME1 was expressed in E.coli and purified by using conventional chromatography techniques.

Alternative Names: Non-metastatic cells 1, Nucleoside diphosphate kinase A, NDP kinase A, AWD, GAAD, NB, NBS, NDPK-A, NM23, NM23-H1.
Molecular Weight 17.1 kDa
Gene ID 4830
UniProt P15531
Pathways Apoptosis, Nucleotide Phosphorylation, Carbohydrate Homeostasis, Ribonucleoside Biosynthetic Process
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1 mg/mL solution in 20 mM Tris-HCl buffer ( pH 7.5) containing 10 % glycerol and 1 mM DTT
Preservative Dithiothreitol (DTT)
Precaution of Use This product contains dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Expiry Date 12 months
Supplier Images
SDS-PAGE (SDS) image for Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1) (AA 1-152) (Active) protein (ABIN1981648) Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1) (AA 1-152) (Active) protein
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