Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-93) (Active) protein (Fc Tag)

Details for Product No. ABIN2002109, Supplier: Log in to see
Protein Name
  • IRH
  • PBSF
  • SCYB12
  • SDF1
  • TLSF
  • TPAR1
  • Pbsf
  • Scyb12
  • Sdf1
  • Tlsf
  • Tpar1
  • sdf-1
  • sdf1
  • xSDF-1
  • SDF-1
  • cxcl12
  • sdf-1a
  • sdf1a
  • wu:fa55e10
  • wu:fc16h12
  • wu:fj84c02
  • C-X-C motif chemokine ligand 12
  • chemokine (C-X-C motif) ligand 12
  • C-X-C motif chemokine ligand 12 L homeolog
  • chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)
  • CXCL12
  • cxcl12
  • Cxcl12
  • cxcl12.L
  • cxcl12a
Protein Characteristics
AA 22-93
13
11
8
5
3
3
2
2
1
1
1
1
1
1
Origin
Human
56
33
11
3
1
1
1
1
Source
Human Cells
91
3
1
1
1
Protein Type
Recombinant
Biological Activity
Active
Purification tag / Conjugate
This CXCL12 protein is labelled with Fc Tag.
Application
Functional Studies (Func), SDS-PAGE (SDS)
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Characteristics The recombinant human SDF1/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 309 amino acids and predicts a molecular mass of 35.2 kDa. As a result of glycosylation, rhSDF1/Fc monomer is approximately 43 kDa in SDS-PAGE under reducing conditions.

Protein Structure: A DNA sequence encoding the N-terminally truncated human SDF1β (NP_000600.1) (Lys 22-Met 93) was expressed with the fused Fc region of human IgG1 at the N-terminus.
Predicted N-Term: Glu 20
Purity > 95 % as determined by SDS-PAGE
Endotoxin Level < 1.0 EU per μg of the protein as determined by the LAL method
Biological Activity Comment Measured by its ability to bind biotinylated recombinant human DPPIV in a functional ELISA.
Background Synonyms: IRH,PBSF,SCYB12,SDF-1,SDF1,TLSF,TPAR1
Molecular Weight 35.2 kDa, 43 kDa
NCBI Accession NP_000600
Pathways Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Handling Advice Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Storage -20 °C,-80 °C
Storage Comment Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Expiry Date 12 months
Supplier Images
 image for Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-93) (Active) protein (Fc Tag) (ABIN2002109) Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-93) (Active) protein (Fc Tag)
Background publications Kryczek, Wei, Keller, Liu, Zou: "Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis." in: American journal of physiology. Cell physiology, Vol. 292, Issue 3, pp. C987-95, 2007

Kryczek, Wei, Keller, Liu, Zou: "Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis." in: American journal of physiology. Cell physiology, Vol. 292, Issue 3, pp. C987-95, 2007 (PubMed).

Orimo, Gupta, Sgroi, Arenzana-Seisdedos, Delaunay, Naeem, Carey, Richardson, Weinberg: "Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion." in: Cell, Vol. 121, Issue 3, pp. 335-48, 2005 (PubMed).

Sapède, Rossel, Dambly-Chaudière, Ghysen: "Role of SDF1 chemokine in the development of lateral line efferent and facial motor neurons." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 5, pp. 1714-8, 2005 (PubMed).

Delgado, Clark-Lewis, Loetscher, Langen, Thelen, Baggiolini, Wolf: "Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes." in: European journal of immunology, Vol. 31, Issue 3, pp. 699-707, 2001 (PubMed).

Bleul, Farzan, Choe, Parolin, Clark-Lewis, Sodroski, Springer: "The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry." in: Nature, Vol. 382, Issue 6594, pp. 829-33, 1997 (PubMed).

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