Spastic Paraplegia 21 (SPG21) (full length), (AA 1-308) protein (GST tag)

Details for Product No. ABIN2002997, Supplier: Log in to see
Protein Name
  • ACP33
  • GL010
  • MAST
  • Maspardin
  • wu:fd07h02
  • zgc:73091
  • BM-019
  • C78576
  • D9Wsu18e
  • spastic paraplegia 21
  • spastic paraplegia 21 (autosomal recessive, Mast syndrome)
  • spastic paraplegia 21 (H. sapiens)
  • spastic paraplegia 21 homolog (human)
  • LOC100345833
  • LOC100358285
  • SPG21
  • spg21
  • Spg21
Protein Characteristics
full length, AA 1-308
8
1
1
1
1
1
1
1
1
Origin
Human
11
2
1
1
1
1
1
1
Source
Baculovirus infected Insect Cells
6
2
2
2
2
1
Protein Type
Recombinant
Purification tag / Conjugate
This SPG21 protein is labelled with GST tag.
Application
SDS-PAGE (SDS)
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Characteristics The recombinant human SPG21/GST chimera consists of 533 amino acids and predicts a molecular mass of 61 kDa which is also estimated by SDS-PAGE.

Protein Structure: A DNA sequence encoding the full length of human SPG21 (NP_057714.1) (Met 1-Gln 308) was expressed with the GST tag at the N-terminus.
Predicted N-Term: Met
Purity > 90 % as determined by SDS-PAGE
Endotoxin Level < 1.0 EU per μg of the protein as determined by the LAL method
Background Synonyms: ACP33,BM-019,GL010,MAST
Molecular Weight 61 kDa
NCBI Accession NP_057714
Research Area Neurology, Adaptive Immunity
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH 8.0, 10 % glycerol
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Handling Advice Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Storage -20 °C,-80 °C
Storage Comment Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Expiry Date 12 months
Supplier Images
 image for Spastic Paraplegia 21 (SPG21) (full length), (AA 1-308) protein (GST tag) (ABIN2002997) Spastic Paraplegia 21 (SPG21) (full length), (AA 1-308) protein (GST tag)
Background publications Hanna, Blackstone: "Interaction of the SPG21 protein ACP33/maspardin with the aldehyde dehydrogenase ALDH16A1." in: Neurogenetics, Vol. 10, Issue 3, pp. 217-28, 2009 (PubMed).

Kedmi, Orr-Urtreger: "Differential brain transcriptome of beta4 nAChR subunit-deficient mice: is it the effect of the null mutation or the background strain?" in: Physiological genomics, Vol. 28, Issue 2, pp. 213-22, 2007

Kedmi, Orr-Urtreger: "Differential brain transcriptome of beta4 nAChR subunit-deficient mice: is it the effect of the null mutation or the background strain?" in: Physiological genomics, Vol. 28, Issue 2, pp. 213-22, 2007 (PubMed).

Simpson, Cross, Proukakis, Pryde, Hershberger, Chatonnet, Patton, Crosby: "Maspardin is mutated in mast syndrome, a complicated form of hereditary spastic paraplegia associated with dementia." in: American journal of human genetics, Vol. 73, Issue 5, pp. 1147-56, 2003

Simpson, Cross, Proukakis, Pryde, Hershberger, Chatonnet, Patton, Crosby: "Maspardin is mutated in mast syndrome, a complicated form of hereditary spastic paraplegia associated with dementia." in: American journal of human genetics, Vol. 73, Issue 5, pp. 1147-56, 2003 (PubMed).

Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Zeitlmann, Sirim, Kremmer, Kolanus: "Cloning of ACP33 as a novel intracellular ligand of CD4." in: The Journal of biological chemistry, Vol. 276, Issue 12, pp. 9123-32, 2001

Zeitlmann, Sirim, Kremmer, Kolanus: "Cloning of ACP33 as a novel intracellular ligand of CD4." in: The Journal of biological chemistry, Vol. 276, Issue 12, pp. 9123-32, 2001 (PubMed).