Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) (AA 31-242) (Active) protein (Fc Tag)

Details for Product No. ABIN2003474, Supplier: Log in to see
Protein Name
  • DKK-1
  • SK
  • dkk1
  • dkk
  • dkk-1
  • xdkk1
  • Xdkk-1
  • Dickkopf1
  • dickkopf-1
  • mdkk-1
  • dkk1-A
  • dickkopf WNT signaling pathway inhibitor 1
  • dickkopf-related protein 1
  • dickkopf WNT signaling pathway inhibitor 1b
  • dickkopf protein
  • dickkopf WNT signaling pathway inhibitor 1 S homeolog
  • DKK1
  • Dkk1
  • LOC100228789
  • dkk1b
  • dkk1
  • dickkopf
  • dkk1.S
Protein Characteristics
AA 31-242
8
3
3
3
2
2
2
2
1
1
1
1
1
1
1
Origin
Human
37
9
2
2
Source
Human Cells
15
13
4
3
3
3
2
2
1
1
1
Protein Type
Recombinant
Biological Activity
Active
Purification tag / Conjugate
This DKK1 protein is labelled with Fc Tag.
Application
Functional Studies (Func), SDS-PAGE (SDS)
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Characteristics The recombinant human DKKL1/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 472 amino acids and has a predicted molecular mass of 52.4 kDa. rhDKKL1/Fc monomer migrates as an approximately 60 kDa protein in SDS-PAGE under reducing conditions.

Protein Structure: A DNA sequence encoding the secreted form of human DKKL1 (Q9UK85) (Ala 31-Leu 242) was expressed with the fused Fc region of human IgG1 at the N-terminus.
Predicted N-Term: Glu
Purity > 70 % as determined by SDS-PAGE
Endotoxin Level < 1.0 EU per μg of the protein as determined by the LAL method
ProductDetails: Biological Activity Comment Measured by its ability to inhibit proliferation of HeLa human cervical epithelial carcinoma cells. The ED50 for this effect is typically 5-15 μg/ml.
Background Synonyms: CT34,SGY,SGY-1,SGY1
Molecular Weight 52.4 kDa, 60 kDa
UniProt Q9UK85
Research Area Stem Cells, Wnt
Pathways WNT Signaling, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Handling Advice Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Storage -20 °C,-80 °C
Storage Comment Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Expiry Date 12 months
Supplier Images
 image for Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) (AA 31-242) (Active) protein (Fc Tag) (ABIN2003474) Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) (AA 31-242) (Active) protein (Fc Tag)
Background publications Kohn, Kaneko, DePamphilis: "DkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome during mammalian spermatogenesis." in: Molecular reproduction and development, Vol. 71, Issue 4, pp. 516-22, 2005

Kohn, Kaneko, DePamphilis: "DkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome during mammalian spermatogenesis." in: Molecular reproduction and development, Vol. 71, Issue 4, pp. 516-22, 2005 (PubMed).

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