Neuregulin 1 (NRG1) (N-Term), (AA 2-246) (Active) protein (Fc Tag,ECD)

Details for Product No. ABIN2004420, Supplier: Log in to see
Protein Name
  • 6030402G23Rik
  • ARIA
  • D230005F13Rik
  • GGF
  • GGFII
  • HRG
  • HRGalpha
  • Hgl
  • NDF
  • SMDF
  • GGF2
  • HGL
  • HRG1
  • HRGA
  • MST131
  • NRG-1
  • heregulin
  • nrg1-A
  • pro-neuregulin-1
  • NRG1
  • wu:fm70e01
  • DKFZp459A1838
  • neuregulin 1
  • neuregulin 1 L homeolog
  • Nrg1
  • NRG1
  • nrg1.L
  • nrg1
Protein Characteristics
N-Term, AA 2-246
5
4
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Origin
Human
37
8
5
3
1
Source
Human Cells
28
14
6
2
2
1
Protein Type
Recombinant
Biological Activity
Active
Purification tag / Conjugate
This Neuregulin 1 protein is labelled with Fc Tag,ECD.
Application
Functional Studies (Func), SDS-PAGE (SDS)
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Characteristics The recombinant human NRG1/mFc is a disulfide-linked homodimer. The reduced monomer comprises 481 amino acids and has a predicted molecular mass of 53.4 kDa. The apparent molecular mass of the monomer is approximately 67 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Protein Structure: A DNA sequence encoding the N-terminal fragment (Ser 2-Lys 246) of human NRG1 isoform beta1 (Q02297-6) was expressed, fused with the Fc region of mouse IgG1 at the N-terminus.
Predicted N-Term: Asp
Purity > 88 % as determined by SDS-PAGE
Endotoxin Level < 1.0 EU per μg of the protein as determined by the LAL method
ProductDetails: Biological Activity Comment 1. Measured by its ability to bind with human ErbB4-His in a functional ELISA.
2. Measured by its ability to bind with human ErbB3-His in a functional ELISA.
Background Synonyms: ARIA,GGF,GGF2,HGL,HRG,HRG1,HRGA,MST131,MSTP131,NDF,Neuregulin 1,NRG1-IT2,SMDF
Molecular Weight 53.4 kDa, 67 kDa
UniProt Q02297
Research Area Neurology, Glia marker
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Handling Advice Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Storage -20 °C,-80 °C
Storage Comment Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Expiry Date 12 months
Supplier Images
 image for Neuregulin 1 (NRG1) (N-Term), (AA 2-246) (Active) protein (Fc Tag,ECD) (ABIN2004420) Neuregulin 1 (NRG1) (N-Term), (AA 2-246) (Active) protein (Fc Tag,ECD)
Background publications Holmes, Sliwkowski, Akita, Henzel, Lee, Park, Yansura, Abadi, Raab, Lewis: "Identification of heregulin, a specific activator of p185erbB2." in: Science (New York, N.Y.), Vol. 256, Issue 5060, pp. 1205-10, 1992 (PubMed).