Interleukin 1 Receptor-Like 1 (IL1RL1) (AA 1-332) protein (His tag)

Details for Product No. ABIN2008684, Supplier: Log in to see
Protein Name
  • DER4
  • Fit-1
  • Ly84
  • ST2L
  • St2
  • St2-rs1
  • T1
  • T1/ST2
  • FIT-1
  • IL33R
  • ST2
  • ST2V
  • FIT1
  • interleukin 1 receptor-like 1
  • Il1rl1
  • IL1RL1
Protein Characteristics
AA 1-332
6
4
2
1
1
1
1
1
1
1
Origin
Mouse (Murine)
18
6
Source
Human Cells
5
4
4
2
2
2
1
1
Protein Type
Recombinant
Purification tag / Conjugate
This IL1RL1 protein is labelled with His tag.
Application
SDS-PAGE (SDS)
Options
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Characteristics The recombinant mouse ST2 comprises 317 amino acids and has a predicted molecular mass of 36.5 kDa. The apparent molecular mass of the protein is approximately 55.7 kDa in SDS-PAGE under reducing conditions.

Protein Structure: A DNA sequence encoding the mouse ST2 (NP_001020773.1) (Met1-Arg332) was expressed with a C-terminal polyhistidine tag.
Predicted N-Term: Ser 27
Purity > 95 % as determined by SDS-PAGE
Endotoxin Level < 1.0 EU per μg of the protein as determined by the LAL method
Background Synonyms: DER4,Fit-1,Ly84,St2,St2-rs1,ST2L,T1,T1/ST2
Molecular Weight 36.5 kDa, 55.7 kDa
NCBI Accession NP_001020773
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
Handling Advice Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage.
Storage -20 °C,-80 °C
Storage Comment Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Expiry Date 12 months
Supplier Images
 image for Interleukin 1 Receptor-Like 1 (IL1RL1) (AA 1-332) protein (His tag) (ABIN2008684) Interleukin 1 Receptor-Like 1 (IL1RL1) (AA 1-332) protein (His tag)
Background publications Hayakawa, Hayakawa, Kume, Tominaga: "Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation." in: The Journal of biological chemistry, Vol. 282, Issue 36, pp. 26369-80, 2007 (PubMed).

Sanada, Hakuno, Higgins, Schreiter, McKenzie, Lee: "IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system." in: The Journal of clinical investigation, Vol. 117, Issue 6, pp. 1538-49, 2007 (PubMed).

Schmitz, Owyang, Oldham, Song, Murphy, McClanahan, Zurawski, Moshrefi, Qin, Li, Gorman, Bazan, Kastelein: "IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines." in: Immunity, Vol. 23, Issue 5, pp. 479-90, 2005 (PubMed).

Trajkovic, Sweet, Xu: "T1/ST2--an IL-1 receptor-like modulator of immune responses." in: Cytokine & growth factor reviews, Vol. 15, Issue 2-3, pp. 87-95, 2004 (PubMed).

Löhning, Stroehmann, Coyle, Grogan, Lin, Gutierrez-Ramos, Levinson, Radbruch, Kamradt: "T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 12, pp. 6930-5, 1998 (PubMed).

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