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NEU1 Protein (AA 48-415) (His tag)

NEU1 Origin: Human Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN2115431
  • Target See all NEU1 Proteins
    NEU1 (Sialidase 1 (Lysosomal Sialidase) (NEU1))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 48-415
    Origin
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human Cells
    Purification tag / Conjugate
    This NEU1 protein is labelled with His tag.
    Purpose
    Recombinant Human Sialidase-1/NEU-1 (C-6His)
    Sequence
    ENDFGLVQPL VTMEQLLWVS GRQIGSVDTF RIPLITATPR GTLLAFAEAR KMSSSDEGAK FIALRRSMDQ GSTWSPTAFI VNDGDVPDGL NLGAVVSDVE TGVVFLFYSL CAHKAGCQVA STMLVWSKDD GVSWSTPRNL SLDIGTEVFA PGPGSGIQKQ REPRKGRLIV CGHGTLERDG VFCLLSDDHG ASWRYGSGVS GIPYGQPKQE NDFNPDECQP YELPDGSVVI NARNQNNYHC HCRIVLRSYD ACDTLRPRDV TFDPELVDPV VAAGAVVTSS GIVFFSNPAH PEFRVNLTLR WSFSNGTSWR KETVQLWPGP SGYSSLATLE GSMDGEEQAP QLYVLYEKGR NHYTESISVA KISVYGTLVD HHHHHH
    Characteristics
    Recombinant Human Sialidase-1 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Glu48-Leu415) of Human NEU1 fused with a 6His tag at the C-terminus.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Sterility
    0.2 μm filtered
    Endotoxin Level
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
    Top Product
    Discover our top product NEU1 Protein
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Reconstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Supplied as a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
    Handling Advice
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Storage
    -80 °C
    Storage Comment
    Store at < -20°C, stable for 6 months after receipt.
    Please minimize freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    NEU1 (Sialidase 1 (Lysosomal Sialidase) (NEU1))
    Alternative Name
    Sialidase-1 (NEU1 Products)
    Synonyms
    NANH Protein, NEU Protein, SIAL1 Protein, MGC81958 Protein, AA407268 Protein, AA407316 Protein, Aglp Protein, Apl Protein, Bat-7 Protein, Bat7 Protein, G9 Protein, Map-2 Protein, Neu Protein, Neu-1 Protein, neuraminidase 1 Protein, neuraminidase 1 (lysosomal sialidase) L homeolog Protein, NEU1 Protein, neu1.L Protein, neu1 Protein, Neu1 Protein
    Background
    Sialidase-1 belongs to the N-acetyl-a neuraminidase family. Sialidase-1 is expressed in many tissues, it is highly expressed in the pancreas, and weakly expressed in the brain. Sialidase-1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Deficiencies in the human enzyme Sialidase-1 leads to sialidosis, a rare lysosomal storage disease. Sialidase-1 has been shown to interact with Cathepsin A (protective protein), β-galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.
    Synonyms: Sialidase-1, Acetylneuraminyl Hydrolase, G9 Sialidase, Lysosomal Sialidase, N-Acetyl-Alpha-Neuraminidase 1, NEU1, NANH
    Molecular Weight
    41.27 kDa
    UniProt
    Q99519
    Pathways
    SARS-CoV-2 Protein Interactome
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