Azurocidin Protein (AA 27-250) (His tag)

Catalog No. ABIN2180608

Product Details

Target: Azurocidin (AZU1) (Azurocidin 1 (AZU1))

Protein Type: Recombinant

Protein Characteristics: AA 27-250

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This Azurocidin protein is labelled with His tag.

Sequence: AA 27-250

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25 kDa. The protein migrates as 32-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: >95 % as determined by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

References

Mayer, Dinkic, Jesenofsky, Klauss, Schirmacher, Dapunt, Hackert, Uhle, Hänsch, Gaida: "Changes in the microarchitecture of the pancreatic cancer stroma are linked to neutrophil-dependent reprogramming of stellate cells and reflected by diffusion-weighted magnetic resonance imaging." in: Theranostics, Vol. 8, Issue 1, pp. 13-30, (2017) (PubMed).

Target Details

Target: Azurocidin (AZU1) (Azurocidin 1 (AZU1))

Alternative Name: Azurocidin (AZU1 Products)

Synonyms: AZAMP Protein, AZU Protein, CAP37 Protein, HBP Protein, HUMAZUR Protein, NAZC Protein, AZU1 Protein, Azurocidin Protein, pHBP Protein, azurocidin 1 Protein, azurocidin Protein, AZU1 Protein, CpipJ_CPIJ007384 Protein

Background: Azurocidin (AZU1) is also known as Heparin-binding protein (HBP), Cationic antimicrobial protein CAP37, is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. which belongs to the peptidase S1 family and elastase subfamily. AZU1 / HBP contains 1 peptidase S1 domain. AZU1 binds heparin. The cytotoxic action of AZU1 is limited to many species of Gram-negative bacteria, this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. AZU1 may play a role in mediating recruitment of monocytes in the second wave of inflammation.

Molecular Weight: 25.0 kDa