BCMA Protein (AA 1-54) (Fc Tag)

Catalog No. ABIN2180644

Product Details

Target: BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: AA 1-54

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This BCMA protein is labelled with Fc Tag.

Sequence: AA 1-54

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 32 kDa. As a result of glycosylation, the protein migrates as 35-40 kDa under reducing (R) condition, and 66 kDa under non-reducing (NR) condition (SDS-PAGE).

Purity: >95 % as determined by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 0.1 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

References

Berahovich, Liu, Zhou, Tsadik, Xu, Golubovskaya, Wu: "Hypoxia Selectively Impairs CAR-T Cells In Vitro." in: Cancers, Vol. 11, Issue 5, (2019) (PubMed).

Berahovich, Zhou, Xu, Wei, Guan, Guan, Harto, Fu, Yang, Zhu, Li, Wu, Golubovskaya: "CAR-T Cells Based on Novel BCMA Monoclonal Antibody Block Multiple Myeloma Cell Growth." in: Cancers, Vol. 10, Issue 9, (2018) (PubMed).

Target Details

Target: BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))

Alternative Name: BCMA (TNFRSF17 Products)

Background: Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.

Molecular Weight: 32.0 kDa

NCBI Accession: NP_001183