CD4 Protein (CD4) (AA 26-390) (Fc Tag)

Catalog No. ABIN2180784

Product Details

Target: CD4

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: AA 26-390

Origin: Rhesus Monkey

Source: HEK-293 Cells

Purification tag / Conjugate: This CD4 protein is labelled with Fc Tag.

Sequence: AA 26-390

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 67 kDa. The protein migrates as 70-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: >95 % as determined by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Target Details

Target: CD4

Alternative Name: CD4 (CD4 Products)

Background: T-cell surface glycoprotein CD4 is also known as T-cell surface antigen T4/Leu-3. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is accessory protein for MHC class-II antigen/T-cell receptor interaction. CD4 induces the aggregation of lipid rafts. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.

Molecular Weight: 67.0 kDa

UniProt: G7N5T8

Pathways: TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events