Ephrin A1 Protein (EFNA1) (AA 19-182) (Fc Tag)

Catalog No. ABIN2180992

Product Details

Target: Ephrin A1 (EFNA1)

Protein Type: Recombinant

Protein Characteristics: AA 19-182

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This Ephrin A1 protein is labelled with Fc Tag.

Sequence: AA 19-182

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 46 kDa. As a result of glycosylation, the protein migrates as 50-55 kDa under reducing (R) condition, and 100-110 kDa under non-reducing (NR) condition (SDS-PAGE).

Purity: >95 % as determined by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM Glycine, pH 7.5

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

References

Swidergall, Solis, Millet, Huang, Lin, Phan, Lazarus, Wang, Yeaman, Mitchell, Filler: "Activation of EphA2-EGFR signaling in oral epithelial cells by Candida albicans virulence factors." in: PLoS pathogens, Vol. 17, Issue 1, pp. e1009221, (2021) (PubMed).

Target Details

Target: Ephrin A1 (EFNA1)

Alternative Name: Ephrin-A1 (EFNA1 Products)

Synonyms: Xefrin-A1 Protein, b61 Protein, ecklg Protein, efl1 Protein, efna1 Protein, efna1a Protein, elfa-a Protein, epha1 Protein, eplg1 Protein, lerk1 Protein, tnfaip4 Protein, xelf-a' Protein, xelfa Protein, AI325262 Protein, B61 Protein, Efl1 Protein, Epl1 Protein, Eplg1 Protein, Lerk1 Protein, ECKLG Protein, EFL1 Protein, EPLG1 Protein, LERK-1 Protein, LERK1 Protein, TNFAIP4 Protein, efna1b Protein, MGC130661 Protein, ephrin-A1 S homeolog Protein, ephrin-A1 Protein, ephrin A1 Protein, ephrin-A1b Protein, ephrin-A1 L homeolog Protein, efna1.S Protein, efna1 Protein, EFNA1 Protein, efna1b Protein, Efna1 Protein, efna1.L Protein

Background: Ephrin-A1 (EFNA1) is also known as EPLG1, LERK1, TNFAIP4, Immediate early response protein B61, which belongs to the ephrin family. EFNA1 contains one ephrin RBD (ephrin receptor-binding) domain. EFNA1 is cell surface GPI-bound ligand for Eph receptors, and is a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. EFNA1 binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. EFNA1 plays an important role in angiogenesis and tumor neovascularization.

Molecular Weight: 46.0 kDa

NCBI Accession: NP_004419

Pathways: RTK Signaling