S100A8 Protein (AA 1-93)
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- Target See all S100A8 Proteins
- S100A8 (S100 Calcium Binding Protein A8 (S100A8))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-93
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Sequence
- AA 1-93
- Characteristics
- This protein carries no "tag". The protein has a calculated MW of 10.8 kDa. The protein migrates as 10.8 kDa under reducing (R) condition (SDS-PAGE).
- Purity
- >95 % as determined by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product S100A8 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C- 8 °C) or 3 months (-20 °C to - 70 °C).
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Broad adsorption of sepsis-related PAMP and DAMP molecules, mycotoxins, and cytokines from whole blood using CytoSorb® sorbent porous polymer beads." in: PLoS ONE, Vol. 13, Issue 1, pp. e0191676, (2017) (PubMed).
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Broad adsorption of sepsis-related PAMP and DAMP molecules, mycotoxins, and cytokines from whole blood using CytoSorb® sorbent porous polymer beads." in: PLoS ONE, Vol. 13, Issue 1, pp. e0191676, (2017) (PubMed).
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- Target
- S100A8 (S100 Calcium Binding Protein A8 (S100A8))
- Alternative Name
- S100A8 (S100A8 Products)
- Synonyms
- 60B8AG Protein, CAGA Protein, CFAG Protein, CGLA Protein, CP-10 Protein, L1Ag Protein, MA387 Protein, MIF Protein, MRP8 Protein, NIF Protein, P8 Protein, Mrp8 Protein, S100A8 Protein, 60B8Ag Protein, AI323541 Protein, B8Ag Protein, CFAg Protein, Caga Protein, p8 Protein, MRP-8 Protein, S100 calcium binding protein A8 Protein, S100 calcium binding protein A8 (calgranulin A) Protein, S100A8 Protein, S100a8 Protein
- Background
- S100 calcium binding protein A8 (S100-A8) is also kown as Cystic fibrosis antigen, Migration inhibitory factor-related protein 8 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF and P8, is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100A8 plays a role in various functions of myeloid cells by forming a heterocomplex with S100A9. S100A8 and S100A9 are known to be overexpressed in certain species of carcinomas. S100A8 may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. S100A8 plays an important role in differentiation of thyroid carcinoma possibly by forming a complex with S100A9. S100A8 and S100A9 may also play a key role in inflammation-associated cancer.
- Molecular Weight
- 10.8 kDa
- Pathways
- Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, S100 Proteins
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