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TGFBR2 Protein (AA 23-159) (Fc Tag)

TGFBR2 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Catalog No. ABIN2181811
  • Target See all TGFBR2 Proteins
    TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 23-159
    Origin
    • 24
    • 11
    • 2
    • 1
    • 1
    Human
    Source
    • 13
    • 8
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This TGFBR2 protein is labelled with Fc Tag.
    Sequence
    AA 23-159
    Characteristics
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Purity
    >95 % as determined by SDS-PAGE.
    Sterility
    0.22 μm filtered
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product TGFBR2 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Handling Advice
    Please avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Zhang, Wang, Xue, Lai, Ji, Jin, Chen: "Nicousamide protects kidney podocyte by inhibiting the TGFβ receptor II phosphorylation and AGE-RAGE signaling." in: American journal of translational research, Vol. 9, Issue 1, pp. 115-125, (2017) (PubMed).

  • Target
    TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))
    Alternative Name
    TGFBR2 (TGFBR2 Products)
    Synonyms
    AAT3 Protein, FAA3 Protein, LDS1B Protein, LDS2B Protein, MFS2 Protein, RIIC Protein, TAAD2 Protein, TGFR-2 Protein, TGFbeta-RII Protein, 1110020H15Rik Protein, AU042018 Protein, DNIIR Protein, RIIDN Protein, TBR-II Protein, TbetaR-II Protein, TbetaRII Protein, TGFBR2 Protein, TBETA-RII Protein, TGFBRII Protein, TGF-beta 2 Protein, Tgfbr2T Protein, cb537 Protein, tgfbr2 Protein, wu:fj05c10 Protein, zgc:110498 Protein, transforming growth factor beta receptor 2 Protein, transforming growth factor, beta receptor II Protein, transforming growth factor, beta receptor 2 Protein, transforming growth factor beta receptor 2b Protein, TGFBR2 Protein, Tgfbr2 Protein, tgfbr2b Protein
    Background
    TGF-beta receptor type-2 (TGFBR2 or TGFR-2) is also known as TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II, TGFβR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGF-β1 / TGFB1 and TGF-β3 / TGFB3 with high affinity and TGF-β2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.
    Molecular Weight
    42.1 kDa
    NCBI Accession
    NP_003233
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