Pertussis Toxin (ARTC) (Active) Protein

Details for Product No. ABIN2452202, Supplier: Log in to see
Protein Name
Origin
Bordetella pertussis
Source
Bordetella pertussis
Protein Type
Native
Biological Activity
Active
Application
Functional Studies (Func)
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Characteristics This product was highly purified (>90 % pure) from Bordetella pertussis strain Tohama by the method of Skelton & Wong. Cytotoxicity of the PT was confirmed by morphological alteration of CHO cells after treatment with 0.1 ng/mL of PT.
Background Perrtussis toxin (PT) is a protein-based AB5-type exotoxin produced by Bordeterra pertussis. PT catalyzes the ADP-ribosylation of the alpha subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt and prevents intracellular signal transduction involving the G proteins. PT consists of one moplecule of each S1 (26 kDa), S2 (22 kDa), S3 (22 kDa), S5 (12 kDa) and two molecule of S4 (12 kDa).
Application Notes 1. Studies on the signal transduction of the trimeric GTP binding proteins.
2. Therapeutic role in treating a number of diseases including hypertention,viral and autoimumune inhibitions.
Restrictions For Research Use only
Format Liquid
Concentration 83 µg/mL
Buffer 10 % glycerol, 10 mM phoshate buffer ( pH 7. 4), 137 mM NaCl
Storage -80 °C
Supplier Images
SDS-PAGE (SDS) image for Pertussis Toxin (ARTC) (Active) protein (ABIN2452202) Pertussis Toxin (ARTC) (Active) protein
SDS-PAGE (SDS) image for Pertussis Toxin (ARTC) (Active) protein (ABIN2452202) Pertussis Toxin (ARTC) (Active) protein (Image 2)
SDS-PAGE (SDS) image for Pertussis Toxin (ARTC) (Active) protein (ABIN2452202) Pertussis Toxin (ARTC) (Active) protein (Image 3)
Product cited in: Skelton, Wong: "Simple, efficient purification of filamentous hemagglutinin and pertussis toxin from Bordetella pertussis by hydrophobic and affinity interaction." in: Journal of clinical microbiology, Vol. 28, Issue 5, pp. 1062-5, 1990 (PubMed).

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